{"id":279,"date":"2018-03-24T21:43:27","date_gmt":"2018-03-24T13:43:27","guid":{"rendered":"http:\/\/www.wuchangsong.com\/?p=279"},"modified":"2018-03-27T09:48:36","modified_gmt":"2018-03-27T01:48:36","slug":"gsea%e5%88%86%e6%9e%90%e6%b5%81%e7%a8%8b","status":"publish","type":"post","link":"http:\/\/www.wuchangsong.com\/?p=279","title":{"rendered":"GSEA\u5206\u6790\u6d41\u7a0b"},"content":{"rendered":"<h3><strong>\u4ec0\u4e48\u662fGSEA\uff1f<\/strong><\/h3>\n<p>\u57fa\u56e0\u96c6\u5bcc\u96c6\u5206\u6790 (Gene Set Enrichment Analysis, GSEA)\u7528\u6765\u8bc4\u4f30\u4e00\u4e2a\u9884\u5148\u5b9a\u4e49\u7684\u57fa\u56e0\u96c6\u7684\u57fa\u56e0\u5728\u4e0e\u8868\u578b\u76f8\u5173\u5ea6\u6392\u5e8f\u7684\u57fa\u56e0\u5217\u8868\u4e2d\u7684\u5206\u5e03\u8d8b\u52bf\uff0c\u4ece\u800c\u5224\u65ad\u5176\u5bf9\u8868\u578b\u7684\u8d21\u732e\u3002\u57fa\u56e0\u96c6\u5408\u5bcc\u96c6\u5206\u6790\u68c0\u6d4b\u57fa\u56e0\u96c6\u5408\u800c\u4e0d\u662f\u5355\u4e2a\u57fa\u56e0\u7684\u8868\u8fbe\u53d8\u5316\uff0c\u56e0\u6b64\u53ef\u4ee5\u5305\u542b\u8fd9\u4e9b\u7ec6\u5fae\u7684\u8868\u8fbe\u53d8\u5316\uff0c\u9884\u671f\u5f97\u5230\u66f4\u4e3a\u7406\u60f3\u7684\u7ed3\u679c\u3002<\/p>\n<h3><strong>GSEA\u539f\u7406<\/strong><\/h3>\n<p>\u7ed9\u5b9a\u4e00\u4e2a\u6392\u5e8f\u7684\u57fa\u56e0\u8868L\u548c\u4e00\u4e2a\u9884\u5148\u5b9a\u4e49\u7684\u57fa\u56e0\u96c6S (\u6bd4\u5982\u7f16\u7801\u67d0\u4e2a\u4ee3\u8c22\u901a\u8def\u7684\u4ea7\u7269\u7684\u57fa\u56e0, \u57fa\u56e0\u7ec4\u4e0a\u7269\u7406\u4f4d\u7f6e\u76f8\u8fd1\u7684\u57fa\u56e0\uff0c\u6216\u540c\u4e00GO\u6ce8\u91ca\u4e0b\u7684\u57fa\u56e0)\uff0cGSEA\u7684\u76ee\u7684\u662f\u5224\u65adS\u91cc\u9762\u7684\u6210\u5458s\u5728L\u91cc\u9762\u662f\u968f\u673a\u5206\u5e03\u8fd8\u662f\u4e3b\u8981\u805a\u96c6\u5728L\u7684\u9876\u90e8\u6216\u5e95\u90e8\u3002\u8fd9\u4e9b\u57fa\u56e0\u6392\u5e8f\u7684\u4f9d\u636e\u662f\u5176\u5728\u4e0d\u540c\u8868\u578b\u72b6\u6001\u4e0b\u7684\u8868\u8fbe\u5dee\u5f02\uff0c\u82e5\u7814\u7a76\u7684\u57fa\u56e0\u96c6S\u7684\u6210\u5458\u663e\u8457\u805a\u96c6\u5728L\u7684\u9876\u90e8\u6216\u5e95\u90e8\uff0c\u5219\u8bf4\u660e\u6b64\u57fa\u56e0\u96c6\u6210\u5458\u5bf9\u8868\u578b\u7684\u5dee\u5f02\u6709\u8d21\u732e\uff0c\u4e5f\u662f\u6211\u4eec\u5173\u6ce8\u7684\u57fa\u56e0\u96c6\u3002<\/p>\n<h3><strong>GSEA\u5206\u6790\u4e2d\u51e0\u4e2a\u5173\u952e\u7684\u6982\u5ff5<\/strong><\/h3>\n<p>\u8ba1\u7b97\u5bcc\u96c6\u5f97\u5206 (ES, enrichment score)\uff0cES\u53cd\u5e94\u57fa\u56e0\u96c6\u6210\u5458s\u5728\u6392\u5e8f\u5217\u8868L\u7684\u4e24\u7aef\u5bcc\u96c6\u7684\u7a0b\u5ea6\u3002\u8ba1\u7b97\u65b9\u5f0f\u662f\uff0c\u4ece\u57fa\u56e0\u96c6L\u7684\u7b2c\u4e00\u4e2a\u57fa\u56e0\u5f00\u59cb\uff0c\u8ba1\u7b97\u4e00\u4e2a\u7d2f\u8ba1\u7edf\u8ba1\u503c\u3002\u5f53\u9047\u5230\u4e00\u4e2a\u843d\u5728s\u91cc\u9762\u7684\u57fa\u56e0\uff0c\u5219\u589e\u52a0\u7edf\u8ba1\u503c\u3002\u9047\u5230\u4e00\u4e2a\u4e0d\u5728s\u91cc\u9762\u7684\u57fa\u56e0\uff0c\u5219\u964d\u4f4e\u7edf\u8ba1\u503c\u3002\u6bcf\u4e00\u6b65\u7edf\u8ba1\u503c\u589e\u52a0\u6216\u51cf\u5c11\u7684\u5e45\u5ea6\u4e0e\u57fa\u56e0\u7684\u8868\u8fbe\u53d8\u5316\u7a0b\u5ea6\uff08\u66f4\u4e25\u683c\u7684\u662f\u4e0e\u57fa\u56e0\u548c\u8868\u578b\u7684\u5173\u8054\u5ea6\uff09\u662f\u76f8\u5173\u7684\u3002\u5bcc\u96c6\u5f97\u5206ES\u6700\u540e\u5b9a\u4e49\u4e3a\u6700\u5927\u7684\u5cf0\u503c\u3002\u6b63\u503cES\u8868\u793a\u57fa\u56e0\u96c6\u5728\u5217\u8868\u7684\u9876\u90e8\u5bcc\u96c6\uff0c\u8d1f\u503cES\u8868\u793a\u57fa\u56e0\u96c6\u5728\u5217\u8868\u7684\u5e95\u90e8\u5bcc\u96c6\u3002<\/p>\n<p>\u8bc4\u4f30\u5bcc\u96c6\u5f97\u5206(ES)\u7684\u663e\u8457\u6027\uff0c\u901a\u8fc7\u57fa\u4e8e\u8868\u578b\u800c\u4e0d\u6539\u53d8\u57fa\u56e0\u4e4b\u95f4\u5173\u7cfb\u7684\u6392\u5217\u68c0\u9a8c (permutation test)\u8ba1\u7b97\u89c2\u5bdf\u5230\u7684\u5bcc\u96c6\u5f97\u5206(ES)\u51fa\u73b0\u7684\u53ef\u80fd\u6027\u3002\u82e5\u6837\u54c1\u91cf\u5c11\uff0c\u4e5f\u53ef\u57fa\u4e8e\u57fa\u56e0\u96c6\u505a\u6392\u5217\u68c0\u9a8c (permutation test)\uff0c\u8ba1\u7b97p-value\u3002<\/p>\n<p>\u591a\u91cd\u5047\u8bbe\u68c0\u9a8c\u77eb\u6b63\uff0c\u9996\u5148\u5bf9\u6bcf\u4e2a\u57fa\u56e0\u5b50\u96c6s\u8ba1\u7b97\u5f97\u5230\u7684ES\u6839\u636e\u57fa\u56e0\u96c6\u7684\u5927\u5c0f\u8fdb\u884c\u6807\u51c6\u5316\u5f97\u5230Normalized Enrichment Score (NES)\u3002\u968f\u540e\u9488\u5bf9NES\u8ba1\u7b97\u5047\u9633\u6027\u7387\u3002\uff08\u8ba1\u7b97NES\u4e5f\u6709\u53e6\u5916\u4e00\u79cd\u65b9\u6cd5\uff0c\u662f\u8ba1\u7b97\u51fa\u7684ES\u9664\u4ee5\u6392\u5217\u68c0\u9a8c\u5f97\u5230\u7684\u6240\u6709ES\u7684\u5e73\u5747\u503c\uff09<\/p>\n<p>Leading-edge subset\uff0c\u5bf9\u5bcc\u96c6\u5f97\u5206\u8d21\u732e\u6700\u5927\u7684\u57fa\u56e0\u6210\u5458\u3002<\/p>\n<h3><strong>MSigDB\u6570\u636e\u5e93<\/strong><\/h3>\n<p><strong>MSigDB<\/strong>\uff08Molecular Signatures Database\uff09\u6570\u636e\u5e93\u4e2d\u5b9a\u4e49\u4e86\u5df2\u77e5\u7684\u57fa\u56e0\u96c6\u5408\uff1ahttp:\/\/software.broadinstitute.org\/gsea\/msigdb<\/p>\n<p>\u5305\u62ecH\u548cC1-C7\u516b\u4e2a\u7cfb\u5217\uff08Collection\uff09\uff0c\u6bcf\u4e2a\u7cfb\u5217\u5185\u5bb9\u4e3a\uff1aH: hallmark gene sets\uff08\u6548\u5e94\uff09\u7279\u5f81\u57fa\u56e0\u96c6\u5408\uff0c\u517150\u7ec4\uff08\u6bd4\u5982\u7ec6\u80de\u51cb\u4ea1\u7279\u5f81\u57fa\u56e0\u96c6\uff09\uff1bC1: positional gene sets \u4f4d\u7f6e\u57fa\u56e0\u96c6\u5408\uff0c\u6839\u636e\u67d3\u8272\u4f53\u4f4d\u7f6e\uff0c\u5171326\u4e2a\uff1bC2: curated gene sets\uff1a\uff08\u4e13\u5bb6\uff09\u5171\u8bc6\u57fa\u56e0\u96c6\u5408\uff0c\u57fa\u4e8e\u901a\u8def\u3001\u6587\u732e\u7b49\uff08\u8fd9\u90e8\u5206\u5305\u62ec\u6211\u4eec\u719f\u6089\u7684KEGG\u4fe1\u53f7\u901a\u8def\uff09\uff1bC3: motif gene sets\uff1a\u6a21\u5f0f\u57fa\u56e0\u96c6\u5408\uff0c\u4e3b\u8981\u5305\u62ecmicroRNA\u548c\u8f6c\u5f55\u56e0\u5b50\u9776\u57fa\u56e0\u4e24\u90e8\u5206\uff1bC4: computational gene sets\uff1a\u8ba1\u7b97\u57fa\u56e0\u96c6\u5408\uff0c\u901a\u8fc7\u6316\u6398\u764c\u75c7\u76f8\u5173\u82af\u7247\u6570\u636e\u5b9a\u4e49\u7684\u57fa\u56e0\u96c6\u5408\uff1bC5: GO gene sets\uff1aGene Ontology \u57fa\u56e0\u672c\u4f53\u8bba\uff0c\u5305\u62ecBP\uff08\u751f\u7269\u5b66\u8fc7\u7a0bbiological process\uff0c\u7ec6\u80de\u539f\u4ef6cellular component\u548c\u5206\u5b50\u529f\u80fdmolecular function\u4e09\u90e8\u5206\uff09\uff1bC6: oncogenic signatures\uff1a\u764c\u75c7\u7279\u5f81\u57fa\u56e0\u96c6\u5408\uff0c\u5927\u90e8\u5206\u6765\u6e90\u4e8eNCBI GEO \u672a\u53d1\u8868\u82af\u7247\u6570\u636e\uff1bC7: immunologic signatures: \u514d\u75ab\u76f8\u5173\u57fa\u56e0\u96c6\u5408\u3002<\/p>\n<p>\u8f6f\u4ef6\u4e0b\u8f7d\uff1a<a href=\"http:\/\/software.broadinstitute.org\/gsea\/downloads.jsp\">http:\/\/software.broadinstitute.org\/gsea\/downloads.jsp<\/a><\/p>\n<p>\u6570\u636e\u683c\u5f0f\uff1a<a href=\"http:\/\/www.broadinstitute.org\/cancer\/software\/gsea\/wiki\/index.php\/Data_formats\">http:\/\/www.broadinstitute.org\/cancer\/software\/gsea\/wiki\/index.php\/Data_formats<\/a><\/p>\n<p>\u4e00\uff1a\u51c6\u5907\u6570\u636e\uff08GSEA \u6392\u5e8f\u9700\u8981\u4e09\u4e2a\u6587\u4ef6\uff0c\u5982\u4e0b\uff09<\/p>\n<p>1.\u8868\u8fbe\u91cf\u6587\u4ef6\uff08*.gct\uff09<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-288\" src=\"http:\/\/www.wuchangsong.com\/wp-content\/uploads\/2018\/03\/QQ\u56fe\u724720180324213917.png\" alt=\"\" width=\"804\" height=\"594\" \/><\/p>\n<p>2.\u8bf4\u660e\u6587\u4ef6\uff08*.cls\uff09<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-289\" src=\"http:\/\/www.wuchangsong.com\/wp-content\/uploads\/2018\/03\/QQ\u56fe\u724720180324214155.png\" alt=\"\" width=\"768\" height=\"549\" \/><\/p>\n<p>3. \u57fa\u56e0\u96c6\u5408\uff08.gmt\uff09<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-292\" src=\"http:\/\/www.wuchangsong.com\/wp-content\/uploads\/2018\/03\/QQ\u56fe\u724720180325220639.png\" alt=\"\" width=\"993\" height=\"529\" \/><\/p>\n<p>or<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-293\" src=\"http:\/\/www.wuchangsong.com\/wp-content\/uploads\/2018\/03\/QQ\u56fe\u724720180325220806.png\" alt=\"\" width=\"1045\" height=\"321\" \/><\/p>\n<p>MSigDB\u63d0\u4f9b\u7684\u6570\u636e\u5e93\u662f\u4eba\u6e90\u7684\uff0c\u6240\u4ee5\u4f60\u7684\u7814\u7a76\u7269\u79cd\u4e0d\u662f\u4eba\u7684\u8bdd\uff0c\u5c31\u9700\u8981\u81ea\u5df1\u5236\u4f5cgmt\u6587\u4ef6\uff0c\u8fd9\u4e5f\u662fGSEA\u5206\u6790\u7684\u96be\u70b9\u548c\u5173\u952e\u6240\u5728<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4ec0\u4e48\u662fGSEA\uff1f \u57fa\u56e0\u96c6\u5bcc\u96c6\u5206\u6790 (Gene Set Enrichment Analysis, GSEA)\u7528\u6765\u8bc4\u4f30\u4e00\u4e2a\u9884\u5148\u5b9a\u4e49\u7684\u57fa\u56e0\u96c6\u7684\u57fa\u56e0\u5728\u4e0e\u8868\u578b\u76f8\u5173\u5ea6\u6392\u5e8f\u7684\u57fa\u56e0\u5217\u8868\u4e2d\u7684\u5206\u5e03\u8d8b\u52bf\uff0c\u4ece\u800c\u5224\u65ad\u5176\u5bf9\u8868\u578b\u7684\u8d21\u732e\u3002\u57fa\u56e0\u96c6\u5408\u5bcc\u96c6\u5206\u6790\u68c0\u6d4b\u57fa\u56e0\u96c6\u5408\u800c\u4e0d\u662f\u5355\u4e2a\u57fa\u56e0\u7684\u8868\u8fbe\u53d8\u5316\uff0c\u56e0\u6b64\u53ef\u4ee5\u5305\u542b\u8fd9\u4e9b\u7ec6\u5fae\u7684\u8868\u8fbe\u53d8\u5316\uff0c\u9884\u671f\u5f97\u5230\u66f4\u4e3a\u7406\u60f3\u7684\u7ed3\u679c\u3002 GSEA\u539f\u7406 \u7ed9\u5b9a\u4e00\u4e2a\u6392\u5e8f\u7684\u57fa\u56e0\u8868L\u548c\u4e00\u4e2a\u9884\u5148\u5b9a\u4e49\u7684\u57fa\u56e0\u96c6S (\u6bd4\u5982\u7f16\u7801\u67d0\u4e2a\u4ee3\u8c22\u901a\u8def\u7684\u4ea7\u7269\u7684\u57fa\u56e0, \u57fa\u56e0\u7ec4\u4e0a\u7269\u7406\u4f4d\u7f6e\u76f8\u8fd1\u7684\u57fa\u56e0\uff0c\u6216\u540c\u4e00GO\u6ce8\u91ca\u4e0b\u7684\u57fa\u56e0)\uff0cGSEA\u7684\u76ee\u7684\u662f\u5224\u65adS\u91cc\u9762\u7684\u6210\u5458s\u5728L\u91cc\u9762\u662f\u968f\u673a\u5206\u5e03\u8fd8\u662f\u4e3b\u8981\u805a\u96c6\u5728L\u7684\u9876\u90e8\u6216\u5e95\u90e8\u3002\u8fd9\u4e9b\u57fa\u56e0\u6392\u5e8f\u7684\u4f9d\u636e\u662f\u5176\u5728\u4e0d\u540c\u8868\u578b\u72b6\u6001\u4e0b\u7684\u8868\u8fbe\u5dee\u5f02\uff0c\u82e5\u7814\u7a76\u7684\u57fa\u56e0\u96c6S\u7684\u6210\u5458\u663e\u8457\u805a\u96c6\u5728L\u7684\u9876\u90e8\u6216\u5e95\u90e8\uff0c\u5219\u8bf4\u660e\u6b64\u57fa\u56e0\u96c6\u6210\u5458\u5bf9\u8868\u578b\u7684\u5dee\u5f02\u6709\u8d21\u732e\uff0c\u4e5f\u662f\u6211\u4eec\u5173\u6ce8\u7684\u57fa\u56e0\u96c6\u3002 GSEA\u5206\u6790\u4e2d\u51e0\u4e2a\u5173\u952e\u7684\u6982\u5ff5 \u8ba1\u7b97\u5bcc\u96c6\u5f97\u5206 (ES, enrichment score)\uff0cES\u53cd\u5e94\u57fa\u56e0\u96c6\u6210\u5458s\u5728\u6392\u5e8f\u5217\u8868L\u7684\u4e24\u7aef\u5bcc\u96c6\u7684\u7a0b\u5ea6\u3002\u8ba1\u7b97\u65b9\u5f0f\u662f\uff0c\u4ece\u57fa\u56e0\u96c6L\u7684\u7b2c\u4e00\u4e2a\u57fa\u56e0\u5f00\u59cb\uff0c\u8ba1\u7b97\u4e00\u4e2a\u7d2f\u8ba1\u7edf\u8ba1\u503c\u3002\u5f53\u9047\u5230\u4e00\u4e2a\u843d\u5728s\u91cc\u9762\u7684\u57fa\u56e0\uff0c\u5219\u589e\u52a0\u7edf\u8ba1\u503c\u3002\u9047\u5230\u4e00\u4e2a\u4e0d\u5728s\u91cc\u9762\u7684\u57fa\u56e0\uff0c\u5219\u964d\u4f4e\u7edf\u8ba1\u503c\u3002\u6bcf\u4e00\u6b65\u7edf\u8ba1\u503c\u589e\u52a0\u6216\u51cf\u5c11\u7684\u5e45\u5ea6\u4e0e\u57fa\u56e0\u7684\u8868\u8fbe\u53d8\u5316\u7a0b\u5ea6\uff08\u66f4\u4e25\u683c\u7684\u662f\u4e0e\u57fa\u56e0\u548c\u8868\u578b\u7684\u5173\u8054\u5ea6\uff09\u662f\u76f8\u5173\u7684\u3002\u5bcc\u96c6\u5f97\u5206ES\u6700\u540e\u5b9a\u4e49\u4e3a\u6700\u5927\u7684\u5cf0\u503c\u3002\u6b63\u503cES\u8868\u793a\u57fa\u56e0\u96c6\u5728\u5217\u8868\u7684\u9876\u90e8\u5bcc\u96c6\uff0c\u8d1f\u503cES\u8868\u793a\u57fa\u56e0\u96c6\u5728\u5217\u8868\u7684\u5e95\u90e8\u5bcc\u96c6\u3002 \u8bc4\u4f30\u5bcc\u96c6\u5f97\u5206(ES)\u7684\u663e\u8457\u6027\uff0c\u901a\u8fc7\u57fa\u4e8e\u8868\u578b\u800c\u4e0d\u6539\u53d8\u57fa\u56e0\u4e4b\u95f4\u5173\u7cfb\u7684\u6392\u5217\u68c0\u9a8c (permutation test)\u8ba1\u7b97\u89c2\u5bdf\u5230\u7684\u5bcc\u96c6\u5f97\u5206(ES)\u51fa\u73b0\u7684\u53ef\u80fd\u6027\u3002\u82e5\u6837\u54c1\u91cf\u5c11\uff0c\u4e5f\u53ef\u57fa\u4e8e\u57fa\u56e0\u96c6\u505a\u6392\u5217\u68c0\u9a8c (permutation test)\uff0c\u8ba1\u7b97p-value\u3002 \u591a\u91cd\u5047\u8bbe\u68c0\u9a8c\u77eb\u6b63\uff0c\u9996\u5148\u5bf9\u6bcf\u4e2a\u57fa\u56e0\u5b50\u96c6s\u8ba1\u7b97\u5f97\u5230\u7684ES\u6839\u636e\u57fa\u56e0\u96c6\u7684\u5927\u5c0f\u8fdb\u884c\u6807\u51c6\u5316\u5f97\u5230Normalized Enrichment Score (NES)\u3002\u968f\u540e\u9488\u5bf9NES\u8ba1\u7b97\u5047\u9633\u6027\u7387\u3002\uff08\u8ba1\u7b97NES\u4e5f\u6709\u53e6\u5916\u4e00\u79cd\u65b9\u6cd5\uff0c\u662f\u8ba1\u7b97\u51fa\u7684ES\u9664\u4ee5\u6392\u5217\u68c0\u9a8c\u5f97\u5230\u7684\u6240\u6709ES\u7684\u5e73\u5747\u503c\uff09 Leading-edge subset\uff0c\u5bf9\u5bcc\u96c6\u5f97\u5206\u8d21\u732e\u6700\u5927\u7684\u57fa\u56e0\u6210\u5458\u3002 MSigDB\u6570\u636e\u5e93 MSigDB\uff08Molecular Signatures Database\uff09\u6570\u636e\u5e93\u4e2d\u5b9a\u4e49\u4e86\u5df2\u77e5\u7684\u57fa\u56e0\u96c6\u5408\uff1ahttp:\/\/software.broadinstitute.org\/gsea\/msigdb \u5305\u62ecH\u548cC1-C7\u516b\u4e2a\u7cfb\u5217\uff08Collection\uff09\uff0c\u6bcf\u4e2a\u7cfb\u5217\u5185\u5bb9\u4e3a\uff1aH: hallmark gene sets\uff08\u6548\u5e94\uff09\u7279\u5f81\u57fa\u56e0\u96c6\u5408\uff0c\u517150\u7ec4\uff08\u6bd4\u5982\u7ec6\u80de\u51cb\u4ea1\u7279\u5f81\u57fa\u56e0\u96c6\uff09\uff1bC1: positional gene sets \u4f4d\u7f6e\u57fa\u56e0\u96c6\u5408\uff0c\u6839\u636e\u67d3\u8272\u4f53\u4f4d\u7f6e\uff0c\u5171326\u4e2a\uff1bC2: curated gene sets\uff1a\uff08\u4e13\u5bb6\uff09\u5171\u8bc6\u57fa\u56e0\u96c6\u5408\uff0c\u57fa\u4e8e\u901a\u8def\u3001\u6587\u732e\u7b49\uff08\u8fd9\u90e8\u5206\u5305\u62ec\u6211\u4eec\u719f\u6089\u7684KEGG\u4fe1\u53f7\u901a\u8def\uff09\uff1bC3: motif gene sets\uff1a\u6a21\u5f0f\u57fa\u56e0\u96c6\u5408\uff0c\u4e3b\u8981\u5305\u62ecmicroRNA\u548c\u8f6c\u5f55\u56e0\u5b50\u9776\u57fa\u56e0\u4e24\u90e8\u5206\uff1bC4: computational gene sets\uff1a\u8ba1\u7b97\u57fa\u56e0\u96c6\u5408\uff0c\u901a\u8fc7\u6316\u6398\u764c\u75c7\u76f8\u5173\u82af\u7247\u6570\u636e\u5b9a\u4e49\u7684\u57fa\u56e0\u96c6\u5408\uff1bC5: GO gene sets\uff1aGene Ontology \u57fa\u56e0\u672c\u4f53\u8bba\uff0c\u5305\u62ecBP\uff08\u751f\u7269\u5b66\u8fc7\u7a0bbiological process\uff0c\u7ec6\u80de\u539f\u4ef6cellular component\u548c\u5206\u5b50\u529f\u80fdmolecular 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