{"id":362,"date":"2018-09-04T17:21:49","date_gmt":"2018-09-04T09:21:49","guid":{"rendered":"http:\/\/www.wuchangsong.com\/?p=362"},"modified":"2018-11-26T20:22:35","modified_gmt":"2018-11-26T12:22:35","slug":"%e7%bb%bc%e8%bf%b0-%e9%b1%bc%e7%b1%bb%e6%b7%8b%e5%b7%b4%e7%bb%86%e8%83%9e%ef%bc%9a%e5%9c%a8%e8%bf%9b%e5%8c%96%e4%b8%8a%e5%92%8c%e5%93%ba%e4%b9%b3%e5%8a%a8%e7%89%a9ill%e7%b1%bb","status":"publish","type":"post","link":"http:\/\/www.wuchangsong.com\/?p=362","title":{"rendered":"\u7efc\u8ff0\u2014\u2014\u9c7c\u7c7b\u6dcb\u5df4\u7ec6\u80de\uff1a\u5728\u8fdb\u5316\u4e0a\u548c\u54fa\u4e73\u52a8\u7269ILL\u7c7b\u4f3c\uff1f"},"content":{"rendered":"

Abstract\uff1a\u6dcb\u5df4\u7ec6\u80de\u662f\u9002\u5e94\u6027\u53cd\u5e94\u7684\u8d23\u4efb\u8005\uff0c\u5c31\u50cf\u7ecf\u5178\u63cf\u8ff0\u7684\u90a3\u6837\uff0c\u4f46\u6709\u8bc1\u636e\u8868\u660e\uff0c\u54fa\u4e73\u52a8\u7269\u6dcb\u5df4\u7ec6\u80de\u7684\u4e9a\u7fa4\u53ef\u80fd\u8868\u73b0\u4e3a\u5148\u5929\u6837\u7ec6\u80de\uff0c\u5feb\u901f\u5730\u53c2\u4e0e\u975e\u81ea\u6211\u6d3b\u52a8\uff0c\u6ca1\u6709\u6297\u539f\u5448\u9012\u3002\u54fa\u4e73\u52a8\u7269\u4f53\u5185\u7684\u7c7b\u6dcb\u5df4\u7ec6\u80de\u4e3b\u8981\u662f\u03b3\u03b4t\u7ec6\u80de\u548cb1-b\u7ec6\u80de\uff0c\u4e3b\u8981\u5728\u7c98\u819c\u7ec4\u7ec7\u4e2d\u53d1\u6325\u4f5c\u7528\u3002\u53ef\u80fd\u4e0e\u4eba\u7c7b\u7684\u75c5\u7406\u6709\u5173\uff0c\u5176\u529f\u80fd\u548c\u7ec4\u7ec7\u7684\u8d77\u6e90\u5c1a\u4e0d\u5b8c\u5168\u6e05\u695a\u3002\u7531\u4e8e\u9c7c\u7c7b\u548c\u54fa\u4e73\u52a8\u7269\u7684\u514d\u75ab\u7cfb\u7edf\u5728\u5f62\u6001\u548c\u514d\u75ab\u751f\u7269\u5b66\u4e0a\u7684\u76f8\u4f3c\u6027\uff0c\u4ee5\u53ca\u5177\u6709\u81ea\u7531\u751f\u6d3b\u7684\u5e7c\u866b\u9636\u6bb5\u7684\u72ec\u7279\u6027\uff0c\u53ef\u4ee5\u7cbe\u786e\u5730\u76d1\u6d4b\u548c\u6539\u9020\u5b83\u4eec\u7684\u53d1\u80b2\uff0c\u56e0\u6b64\u63d0\u51fa\u4e86\u4e00\u79cd\u7814\u7a76\u4eba\u7c7b\u514d\u75ab\u7684\u5b9e\u9a8c\u6a21\u578b-\u786c\u9aa8\u9c7c\u3002\u7136\u800c\uff0c\u9c7c\u7c7b\u6dcb\u5df4\u7ec6\u80de\u4e0e\u54fa\u4e73\u52a8\u7269\u5148\u5929\u6837\u6dcb\u5df4\u7ec6\u80de\u4e4b\u95f4\u7684\u540c\u6e90\u6027\u662f\u6bd4\u8f83\u514d\u75ab\u5b66\u4e2d\u8003\u8651\u8f83\u5c11\u7684\u4e00\u4e2a\u95ee\u9898\u3002\u8d8a\u6765\u8d8a\u591a\u7684\u5b9e\u9a8c\u8bc1\u636e\u8868\u660e\uff0c\u9c7c\u7c7b\u6dcb\u5df4\u7ec6\u80de\u5728\u53d1\u80b2\u3001\u5f62\u6001\u548c\u529f\u80fd\u7279\u5f81\u4e0a\u53ef\u80fd\u4e0e\u54fa\u4e73\u52a8\u7269\u7684\u5148\u5929\u6837\u6dcb\u5df4\u7ec6\u80de\u6709\u5171\u540c\u4e4b\u5904\u3002\u5c3d\u7ba1\u6709\u8fd9\u4e9b\u76f8\u4f3c\u4e4b\u5904\uff0c\u4f46\u5173\u4e8e\u4f20\u7edf\u9c7c\u7c7b\u6dcb\u5df4\u7ec6\u80de\u548c\u54fa\u4e73\u52a8\u7269\u5148\u5929\u6837\u6dcb\u5df4\u7ec6\u80de\u4e4b\u95f4\u53ef\u80fd\u5b58\u5728\u8054\u7cfb\u7684\u4fe1\u606f\u4ecd\u7136\u7f3a\u4e4f\u3002\u672c\u6587\u65e8\u5728\u603b\u7ed3\u548c\u63cf\u8ff0\u9c7c\u7c7b\u6dcb\u5df4\u7ec6\u80de\u4e0e\u54fa\u4e73\u52a8\u7269\u5148\u5929\u6837\u6dcb\u5df4\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4f3c\u6027\uff0c\u652f\u6301\u54fa\u4e73\u52a8\u7269\u03b3\u03b4t\u7ec6\u80de\u548cb1-b\u7ec6\u80de\u53ef\u80fd\u4e0e\u9c7c\u7c7b\u6dcb\u5df4\u7ec6\u80de\u8fdb\u5316\u76f8\u5173\u7684\u5047\u8bf4\u3002<\/p>\n

Introduction\uff1a\u53ea\u67092%\u7684\u540e\u751f\u52a8\u7269\u5b58\u5728\u5177\u6709mhc\u3001rag\u3001 memory \u7684\u810a\u690e\u52a8\u7269\u578b\u9002\u5e94\u6027\u53cd\u5e94\uff0c\u4f46\u662f\u5728\u5148\u5929\u514d\u75ab\u9632\u5fa1\u4fdd\u62a4\u4e0b\u65e0\u810a\u690e\u52a8\u7269\u53ef\u4ee5\u6d3b\u5f88\u957f\u65f6\u95f4\u3002\u4e8b\u5b9e\u4e0a\uff0c\u4f20\u7edf\u4e0a\u88ab\u5b9a\u4e49\u4e3a\u53ea\u4f9d\u8d56\u5148\u5929\u53cd\u5e94\u7684\u65e0\u810a\u690e\u52a8\u7269\u53ef\u80fd\u6d3b\u51e0\u4e2a\u4e16\u7eaa\uff0c\u5e76\u88ab\u53d1\u73b0\u5bf9\u518d\u611f\u67d3\u6709\u53cd\u5e94\uff0c\u8fd9\u8868\u660e\u5148\u5929\u514d\u75ab\u673a\u5236\u9700\u8981\u66f4\u591a\u7684\u7814\u7a76\u3002\u4ece\u6bd4\u8f83\u514d\u75ab\u5b66\u7684\u89c2\u70b9\u6765\u770b\uff0c\u53ef\u4ee5\u63a8\u6d4b\u5728\u810a\u690e\u52a8\u7269\u8fdb\u5316\u65e9\u671f\u51fa\u73b0\u7684\u767d\u7ec6\u80de\u7fa4\u7ee7\u627f\u5e76\u4fdd\u7559\u4e86\u4e00\u4e9b\u4e0e\u6297\u539f\u8bc6\u522b\u548c\u6e05\u9664\u76f8\u5173\u7684\u65e0\u810a\u690e\u52a8\u7269\u7279\u5f81\u3002\u5728\u8fdb\u5316\u8fc7\u7a0b\u4e2d\uff0c\u7f16\u7801\u514d\u75ab\u6d3b\u6027\u7684\u57fa\u56e0\u4ee5\u201c layers\u201d\u7684\u5f62\u5f0f\u5411\u54fa\u4e73\u52a8\u7269\u805a\u96c6\u3002\u8fd9\u4e00\u5047\u8bf4\u8ba4\u4e3a\uff0c\u8fdb\u5316\u4ea7\u751f\u4e86\u4e00\u79cd\u5c42\u6b21\u6027\u7684\u514d\u75ab\u7cfb\u7edf\uff0c\u5728\u8fd9\u79cd\u7cfb\u7edf\u4e2d\uff0c\u540e\u6765\u7269\u79cd\u5728\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u83b7\u5f97\u4e86\u4f18\u52bf\u5730\u4f4d\uff0c\u4ece\u800c\u4ea7\u751f\u4e86\u8d1f\u8d23\u8d8a\u6765\u8d8a\u590d\u6742\u7684\u514d\u75ab\u6d3b\u6027\u7684\u7ec6\u80de\u7fa4\u4f53\u3002\u56e0\u4e3a\u4eba\u4eec\u666e\u904d\u8ba4\u4e3a\u201c\u4e2a\u4f53\u53d1\u80b2\u7c7b\u4f3c\u4e8e\u7cfb\u7edf\u53d1\u80b2\u201d\uff0c\u201c\u5206\u5c42\u514d\u75ab\u7cfb\u7edf\u201d\u5047\u8bf4\u53ef\u80fd\u4e3a\u4e86\u89e3\u810a\u690e\u52a8\u7269\u7684\u7ec6\u80de\u529f\u80fd\u63d0\u4f9b\u7ebf\u7d22\uff0c\u5e76\u4e3a\u66f4\u597d\u5730\u7406\u89e3\u4eba\u7c7b\u7684\u75c5\u7406\u63d0\u4f9b\u77e5\u8bc6\u3002<\/p>\n

\u5148\u5929\u514d\u75ab\u53cd\u5e94\u662f\u5bf9\u611f\u67d3\u548c\u4f24\u5bb3\u7684\u7b2c\u4e00\u7ea7\u9632\u62a4\uff0c\u901a\u8fc7\u79cd\u7cfb\u7f16\u7801\u53d7\u4f53\u7684\u7ec6\u80de\u5bf9\u975e\u6211\u6216\u635f\u4f24\u5feb\u901f\u505a\u51fa\u53cd\u5e94\u3002\u5728\u54fa\u4e73\u52a8\u7269\u4e2d\uff0c\u6709\u4e0d\u540c\u7c7b\u578b\u7684\u5148\u5929\u514d\u75ab\u7ec6\u80de\uff0c\u9664\u4e86\u5de8\u566c\u7ec6\u80de\/\u6811\u7a81\u72b6\u7ec6\u80de\/\u4e2d\u6027\u7c92\u7ec6\u80de\u4e4b\u5916\uff0c\u8fd8\u53d1\u73b0\u4e86\u5148\u5929\u6837\u6dcb\u5df4\u7ec6\u80de\uff08ILC\uff09\u3002\u6839\u636e\u8868\u8fbe\u7684\u8f6c\u5f55\u56e0\u5b50\uff0c\u529f\u80fd\u7279\u5f81\u548c\u8868\u578b\u53ef\u4ee5\u628aILC\u5206\u4e3a\u4e09\u7c7b\u3002\u53e6\u4e00\u7ec4\u54fa\u4e73\u52a8\u7269\u7684\u975e\u5e38\u89c4\u6216\u5148\u5929\u6837\u6dcb\u5df4\u7ec6\u80de\uff08mILL\uff09\u6839\u636e\u5177\u6709\u7279\u6027\u548c\u529f\u80fd\uff0c\u88ab\u8ba4\u4e3a\u662f\u5148\u5929\u548c\u9002\u5e94\u6027\u53cd\u5e94\u4e4b\u95f4\u7684\u6865\u6881\u3002mILL\u4e9a\u7fa4\u53ef\u80fd\u4f1a\u518d\u6b21\u51fa\u73b0\u4e00\u4e2a\u201c\u514d\u75ab\u4e0b\u5c42\u201d\u4ea7\u751f\u9057\u4f20\u800c\u6765\u7684\u5929\u7136\u591a\u53cd\u5e94\u6297\u4f53\u548c\u5178\u578b\u7684\u7ec6\u80de\u56e0\u5b50\u6a21\u5f0f\uff0c\u7528\u6765\u7ef4\u6301\u80a0\u9053\u7a33\u6001\u3001\u65e9\u671f\u5bf9\u80a0\u9053\u611f\u67d3\u7684\u53cd\u5e94\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u548c\u764c\u75c7\u3001\u5feb\u901f\u65e0\u51c6\u5907\u5730\u5bf9\u6297\u611f\u67d3\u548c\u635f\u5bb3\u3002\u8be5\u7ec6\u80de\u4e3b\u8981\u88ab\u9274\u5b9a\u4e3a\u03b3\u03b4t\u7ec6\u80de\u548cb1-b\u7ec6\u80de\uff0c\u4e3b\u8981\u5206\u5e03\u5728\u7c98\u819c\u7ec4\u7ec7\u4e2d\uff0c\u5176\u529f\u80fd\u548c\u8d77\u6e90\u4ecd\u6709\u5f85\u8fdb\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n

\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0c\u5e38\u89c4\u9c7c\u7c7b\u6dcb\u5df4\u7ec6\u80de\u663e\u793a\u51fa\u4e0emILL\u4e00\u4e9b\u76f8\u540c\u7684\u53d1\u80b2\u3001\u5f62\u6001\u548c\u529f\u80fd\u7279\u5f81\uff0c\u800c\u4e14\u6700\u8fd1\u8fd9\u4e9b\u76f8\u4f3c\u6027\u5f15\u8d77\u4e86\u514d\u75ab\u5b66\u5bb6\u7684\u6ce8\u610f\u3002\u7136\u800c\uff0c\u65e8\u5728\u6f84\u6e05\u9c7c\u7c7b\u6dcb\u5df4\u7ec6\u80de\u4e0emILL\u4e4b\u95f4\u8054\u7cfb\u7684\u7814\u7a76\u8fd8\u5904\u4e8e\u521a\u5f00\u59cb\u9636\u6bb5\u3002<\/p>\n

\u672c\u6587\u7efc\u8ff0\u4e86\u76ee\u524d\u5173\u4e8e\u9c7c\u7c7b\u6dcb\u5df4\u7ec6\u80de\u4e0emILL\u4e4b\u95f4\u53ef\u80fd\u76f8\u4f3c\u7684\u77e5\u8bc6\uff0c\u5e76\u5229\u7528\u8fd9\u4e9b\u77e5\u8bc6\u63d0\u51fa\u4e86\u8fd9\u6837\u7684\u5047\u8bbe\uff1a\u5927\u591a\u6570\u9c7c\u7c7b\u6dcb\u5df4\u7ec6\u80de\u8868\u73b0\u4e3amILL\u7684\u7c7b\u4e9a\u7fa4\u4f53\uff0c\u56e0\u6b64\uff0cmILL\u4e9a\u7fa4(\u03b3\u03b4t\u7ec6\u80de\uff0cb1-b\u7ec6\u80de)\u53ef\u4ee5\u4ee3\u8868\u73b0\u5b58\u7684\u3001\u8fdb\u5316\u76f8\u5173\u7684\u9c7c\u7c7b\u6dcb\u5df4\u7ec6\u80de\u7684\u201c\u4e0b\u5c42\u201d\u3002<\/p>\n

\u54fa\u4e73\u52a8\u7269\u5148\u5929\u6837\u6dcb\u5df4\u7ec6\u80de\uff1a<\/strong><\/p>\n

ILC\u662f\u54fa\u4e73\u52a8\u7269\u5929\u7136\u514d\u75ab\u6d3b\u52a8\u7684\u91cd\u8981\u53c2\u4e0e\u8005\uff0c\u5b83\u6765\u6e90\u4e8e\u4e00\u79cd\u5e38\u89c1\u7684\u6dcb\u5df4\u524d\u4f53\uff0c\u5728\u5929\u7136\u514d\u75ab\u548c\u7ec4\u7ec7\u91cd\u5efa\u4e2d\u53d1\u6325\u7740\u6548\u5e94\u548c\u8c03\u8282\u4f5c\u7528\u3002ILC\u8868\u9762\u6ca1\u6709TCR\u6216Ig\u91cd\u6392\u7684\u53d7\u4f53\uff0c\u6839\u636e\u5b83\u4eec\u4ea7\u751f\u7684\u7ec6\u80de\u56e0\u5b50\u53ca\u5176\u529f\u80fd\u6240\u5fc5\u9700\u7684\u8f6c\u5f55\u56e0\u5b50\u7684\u6a21\u5f0f\u5c06\u5176\u5206\u4e3a\u4e09\u7c7b\uff1aILC1\u4ea7\u751f\u5e72\u6270\u7d20\u03b3\u5e76\u4f9d\u8d56\u4e8eTbet\uff0cILC2\u4ea7\u751f2\u578b\u7ec6\u80de\u56e0\u5b50(IL-5\/IL-13)\uff0c\u9700\u8981GATA 3\uff0cILC3\u4f9d\u8d56\u4e8eROR\u03b3t\u5e76\u4ea7\u751fIL-17\u548c\/\u6216IL-22\u3002\u81ea\u7136\u6740\u4f24\u7ec6\u80de(NK)\u5c5e\u4e8e\u5148\u5929\u6dcb\u5df4\u7ec6\u80de\uff0c\u53c2\u4e0e\u5feb\u901f\u7684\u5148\u5929\u53cd\u5e94\uff0c\u8868\u9762\u4e0d\u8868\u8fbeCD3\u6216\u6dcb\u5df4\u7ec6\u80de\u53d7\u4f53\u3002\u7136\u800c\uff0c\u9664\u4e86\u7ecf\u5178\u63cf\u8ff0\u6dcb\u5df4\u7ec6\u80de\u662f\u8d1f\u8d23\u9002\u5e94\u6027\u53cd\u5e94\u7684\u7ec6\u80de\u5916\uff0c\u6700\u8fd1\u53d1\u73b0\u7684mIL\u4e9a\u7fa4\u4f53\u5728\u4e4b\u524d\u7814\u7a76\u7684\u5148\u5929\u9002\u5e94\u5206\u7c7b\u4e2d\u8868\u73b0\u4e3a\u5148\u5929\u514d\u75ab\u7ec6\u80de\u3002<\/p>\n

mILL\u53c2\u4e0e\u7ef4\u6301\u80a0\u9053\u5185\u7a33\u6001\uff0c\u5e76\u53c2\u4e0e\u5bf9\u80a0\u9053\u611f\u67d3\u7684\u65e9\u671f\u53cd\u5e94\uff0c\u5728\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u4e0e\u764c\u75c7\u4e2d\u80fd\u591f\u4ee5\u72ec\u7acb\u4e8eMHC\u7684\u65b9\u5f0f\u4ea7\u751f\u65e0\u504f\u7684\u5929\u7136\u591a\u53cd\u5e94\u6297\u4f53\u548c\u5178\u578b\u7684\u7ec6\u80de\u56e0\u5b50\u6a21\u5f0f\u5bf9\u6297\u975e\u81ea\u6211\u3002<\/p>\n

\u54fa\u4e73\u52a8\u7269\u8868\u73b0\u51fa\u5148\u5929\u6837\u6d3b\u6027\u7684\u4e3b\u8981\u6dcb\u5df4\u7ec6\u80de\u4e9a\u7fa4\u5df2\u88ab\u786e\u8ba4\u4e3a\u03b3\u03b4t\u7ec6\u80de\uff0c\u7c98\u6db2\u76f8\u5173\u4e0d\u53d8T\u7ec6\u80de(MAIT)\uff0c\u81ea\u7136\u6740\u4f24T\u7ec6\u80de(NKT)\uff0cB1-B\u7ec6\u80de\uff0c\u813e\u8fb9\u7f18\u533aB\u7ec6\u80de\u3002<\/p>\n

\u5148\u5929\u6837<\/strong>T<\/strong>\u7ec6\u80de<\/strong><\/p>\n

\u03b3\u03b4t\u6dcb\u5df4\u7ec6\u80de\u4e3a\u975e\u5e38\u89c4t\u6dcb\u5df4\u7ec6\u80de\uff0c\u5305\u62ec\u8840\u6db2\u4e2d\u8f83\u5c0f\u7684T\u7ec6\u80de\u4e9a\u7fa4\u548c\u5177\u6709\u5178\u578b\u6dcb\u5df4\u7ec6\u80de\u5f62\u6001\u7279\u5f81\u7684\u80a0\u4e0a\u76ae\u5185\u6dcb\u5df4\u7ec6\u80de(IELs)\uff0c\u5176\u8868\u9762\u8c31\u7cfbTCR\u8868\u578b\u4e3a\u03b3+\u03b4+ (mostly displaying repertoires V\u03b41\/C\u03b31 and V\u03b39\/V\u03b42)\uff0c\u5e76\u8868\u73b0\u51fa\u5bf9\u53ef\u6eb6\u6027\u548c\u9897\u7c92\u6027\u6297\u539f\u7684\u5f3a\u5927\u541e\u566c\u80fd\u529b\u3002\u5173\u4e8e\u514d\u75ab\u7403\u86cb\u767d\u548c\u03b1\u03b2TCR\u5206\u5b50\uff0c\u03b3\u03b4TCR\u5728vdj\u91cd\u7ec4\u4ea7\u751f\u7684cdr3\u533a\u57df\u4e2d\uff0c\u5229\u7528v\u94fe\u57fa\u56e0\u663e\u793a\u51fa\u6700\u9ad8\u7684\u81ea\u53d1\u591a\u6837\u6027\u3002\u03b3\u03b4t\u7ec6\u80de\u53ef\u4ee5\u5728\u80f8\u817a\u5916\u548c\u72ec\u7acb\u4e8e\u6297\u539f\u76f8\u9047\u7684\u60c5\u51b5\u4e0b\u53d1\u80b2\uff0c\u5e76\u4e14\u662f\u9002\u5e94\u6027\u548c\u5148\u5929\u6837\u514d\u75ab\u53cd\u5e94\u7684\u6d3b\u8dc3\u53c2\u4e0e\u8005\uff0c\u4f8b\u5982\u76f4\u63a5\u6740\u6b7b\u53d7\u611f\u67d3\u7684\u7ec6\u80de\uff0c\u53c2\u4e0e\u80bf\u7624\u514d\u75ab\u76d1\u6d4b\uff0c\u4ea7\u751f\u75c5\u539f\u4f53\u6e05\u9664\u6240\u9700\u7684\u5206\u5b50\uff0c\u81ea\u53d1\u7ec6\u80de\u6bd2\u6027\uff0c\u91ca\u653e\u514d\u75ab\u8c03\u8282\u7ec6\u80de\u56e0\u5b50\uff0c\u5e76\u4e14\u53ef\u4ee5\u88ab\u5e94\u6fc0\u8bf1\u5bfc\u7684\u5206\u5b50(MIC-A\/B\uff0cULBPs)\u6fc0\u6d3b\uff0c\u4ea7\u751f\u4fc3\u708e\u75c7\u7ec6\u80de\u56e0\u5b50\u548c\u6eb6\u89e3\u9176\u3002\u603b\u4e4b\uff0c\u6709\u8bc1\u636e\u8868\u660e\u03b3\u03b4t\u7ec6\u80de\u8d77\u7740\u6548\u5e94\u548c\u8c03\u8282\u7684\u4f5c\u7528\uff0c\u4ee3\u8868\u4e86\u5177\u6709\u5148\u5929\u548c\u9002\u5e94\u6027\u514d\u75ab\u529f\u80fd\u7684\u8fdb\u5316\u539f\u59cbT\u7ec6\u80de\u5b50\u96c6\u3002\u6700\u8fd1\u7684\u6570\u636e\u4e5f\u8bc1\u5b9e\u4e86\u8fd9\u4e9b\u53d1\u73b0\uff0c\u540c\u65f6\u4e5f\u663e\u793a\u4e86\u03b3\u03b4T\u7ec6\u80de\u4e9a\u7fa4\u7684\u5b58\u5728\uff0c\u8fd9\u4e9b\u7ec6\u80de\u4e9a\u7fa4\u7684\u5148\u5929\u523a\u6fc0\u6bd4TCR\u66f4\u91cd\u8981\uff0c\u5982\u4ea7\u751fIL-17(\u03b3\u03b4T-17)\u548cIFN-\u03b3(\u03b3\u03b4T-IFN\u03b3)\u7684T\u7ec6\u80de\u3002<\/p>\n

\u6700\u8fd1\u53d1\u73b0\u7684\u54fa\u4e73\u52a8\u7269\u5148\u5929\u6837t\u6dcb\u5df4\u7ec6\u80de\u7684\u5176\u4ed6\u4e9a\u7fa4\u662fMAIT\u548cNKT\u3002MAIT\u662f\u4e00\u79cd\u56fa\u6709\u7684t\u7ec6\u80de\u4e9a\u7fa4\uff0c\u4e3b\u8981\u53c2\u4e0e\u7c98\u819c\u8868\u9762\u7684\u6297\u83cc\u514d\u75ab\uff0c\u4e3b\u8981\u5b58\u5728\u4e8e\u4eba\u800c\u4e0d\u662f\u5c0f\u9f20\uff0c\u5b83\u4eec\u8868\u73b0\u4e3a\u79cd\u7cfbTCR\u03b1\u03b2\u8868\u578b(V\u03b17.2-J\u03b133\/12\/20 in humans, V\u03b119-J\u03b133 in mice)\u548c\u53ef\u53d8\u4f46\u53d7\u9650\u5236\u7684TCR\u03b2\u94fe\u3002MAIT\u5728\u523a\u6fc0\u540e\u4ea7\u751f\u8c03\u8282\u6027\u7ec6\u80de\u56e0\u5b50IFN-\u03b3\u3001TNF-\u03b1\u548cIL-17\uff0c\u5e76\u8868\u8fbeIL-7\u3001IL-12\u548cIL-18\u53d7\u4f53\u3002<\/p>\n

NKT\u662f\u03b1\u03b2-\u548c\u03b3\u03b4-t\u7ec6\u80de\u7684\u4e00\u4e2a\u4e9a\u7fa4\u4f53\uff0c\u4e0eNK\u7ec6\u80de\u4e0d\u540c\uff0c\u5176\u7279\u5f81\u662fCD1d\u9650\u5236\u548c\u6709\u9650\u7684tcr\u591a\u6837\u6027\u3002\u5b83\u4eec\u4e3b\u8981\u5b58\u5728\u4e8e\u975e\u7c98\u819c\u7ec4\u7ec7\u4e2d\uff0c\u53c2\u4e0e\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u6709\u52a9\u4e8eb\u7ec6\u80de\u7684\u589e\u6b96\u548c\u6297\u4f53\u7684\u4ea7\u751f\u3002NKT\u53ef\u8fdb\u4e00\u6b65\u5206\u4e3a\u4e24\u4e2a\u4e0d\u540c\u7684\u4e9a\u7fa4\uff0c\u5373\u2160\u578b\u548c\u2161\u578bNKT\u7ec6\u80de\uff0c\u5b83\u4eec\u4f18\u5148\u4f4d\u4e8e\u809d\u810f\u5185\u3002\u2160\u578b\u5728\u5c0f\u9f20\u4e0a\u663e\u793a\u534a\u4e0d\u53d8TcR (V\u03b114J\u03b118\/V\u03b22, 7, 8)\uff0c\u5728\u4eba\u8eab\u4e0a\u663e\u793a(V\u03b124J\u03b118\/V\u03b211)\uff0c\u800c\u2161\u578bNKT\u7ec6\u80de\u8868\u73b0\u51fa\u66f4\u591a\u6837\u5316\u7684TCR\u5e8f\u5217\u3002<\/p>\n

\u5148\u5929\u6837<\/strong>B<\/strong>\u6dcb\u5df4\u7ec6\u80de<\/strong><\/p>\n

\u54fa\u4e73\u52a8\u7269\u7684b\u6dcb\u5df4\u7ec6\u80de\u73b0\u5728\u88ab\u5206\u7c7b\u4e3ab2\uff0c\u6216\u7ecf\u5178\u7684\uff0cb1\uff0c\u6216\u5148\u5929\u7684\u3002\u901a\u8fc7 Cd5\u5728\u5176\u8868\u9762\u7684\u5dee\u5f02\u5b9a\u4e49\u8fd9\u4e24\u7ec4\u4e3b\u8981\u7684b\u6dcb\u5df4\u7ec6\u80de\u3002B1a (B1)\u7ec6\u80de\u8fdb\u4e00\u6b65\u7ec6\u5206\u4e3aB1-B\uff0c\u8868\u578bCD5+\/IgMhigh\/IgDlow\uff0c\u548cCD5\u9634\u6027\u7684B-1b\u3002b1-b\u7ec6\u80de\u4ee5\u4e0d\u4f9d\u8d56T\u7ec6\u80de\u7684\u65b9\u5f0f\u4ea7\u751f\u5927\u91cf\u5929\u7136\u591a\u53cd\u5e94\u6297\u4f53\uff0c\u662f\u79ef\u6781\u541e\u566c\u548c\u6740\u5fae\u751f\u7269\uff0c\u53ef\u80fd\u53c2\u4e0e\u81ea\u8eab\u514d\u75ab\uff0c\u5728\u611f\u67d3\u671f\u95f4\uff0c\u5b83\u4eec\u5728\u80a0\u7c98\u819c\u4e2d\u4ee5\u5206\u6ccciga\u7684\u6d46\u7ec6\u80de\u7684\u5f62\u5f0f\u5b58\u5728\u3002CD5+ B\u7ec6\u80de\u4ea7\u751f\u7684\u5929\u7136\u591a\u53cd\u5e94\u6297\u4f53\u662f\u79cd\u7cfb\u7ec6\u80de\u7f16\u7801\u7684\u6297\u539f\u8bc6\u522b\u5206\u5b50(class IgM, IgA, and IgG3)\uff0c\u5177\u6709\u6709\u9650\u7684v\u533a\u57fa\u56e0\uff0c\u5728\u65e9\u671f\u5bbf\u4e3b\u9632\u5fa1\u3001\u81ea\u566c\/\u7ec4\u7ec7\u91cd\u5851\u548c\u514d\u75ab\u8c03\u8282\u3001\u901a\u8fc7\u8865\u4f53\u6fc0\u6d3b\u7684\u7ecf\u5178\u9014\u5f84\u8bc6\u522b\u75c5\u539f\u4f53\u548c\u6fc0\u6d3b\u5929\u7136\u514d\u75ab\u7cfb\u7edf\u7b49\u65b9\u9762\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002b1-b\u7ec6\u80de\u88ab\u8ba4\u4e3a\u6ca1\u6709\u8bb0\u5fc6\u80fd\u529b\uff0c\u5728\u80da\u80ce\u671f\u65f6\u5b58\u5728\u4e8e\u5c0f\u9f20\u809d\u810f\uff0c\u800c\u5728\u957f\u5927\u540e\u5219\u5b58\u5728\u4e8e\u813e\u810f\u548c\u8179\u819c\u8154\uff0c\u5728\u90a3\u91cc\u5b83\u4eec\u7ecf\u5386\u81ea\u6211\u66f4\u65b0\uff0c\u5176\u673a\u5236\u5c1a\u4e0d\u6e05\u695a\u3002<\/p>\n

b1-b\u7ec6\u80de\u53c2\u4e0e\u5148\u5929\u6d3b\u52a8\uff0c\u5728\u4f53\u5916\u901a\u8fc7TLRs(\u4eceTLR 1\u5230TLR 8)\u5bf9\u523a\u6fc0\u4f5c\u51fa\u53cd\u5e94\uff0c\u8bf1\u5bfcb1-b\u7ec6\u80de\u589e\u6b96\u5e76\u5206\u5316\u4e3a\u514d\u75ab\u7403\u86cb\u767d\u5206\u6ccc\u7ec6\u80de\u3002\u6b64\u5916\uff0cb1-b\u7ec6\u80de\u5728\u5148\u5929\u6fc0\u6d3b\u540e\u80fd\u5feb\u901f\u4ea7\u751f\u5927\u91cf\u7684\u514d\u75ab\u8c03\u8282\u7ec6\u80de\u56e0\u5b50il-10\u3002\u53e6\u4e00\u4e2a\u5177\u6709\u5148\u5929\u6d3b\u6027\u7684b\u7ec6\u80de\u4e9a\u7fa4\u4f4d\u4e8e\u813e\u9ad3\u8fb9\u7f18\u533a\uff0c\u53c2\u4e0e\u4ee5\u4e0d\u4f9d\u8d56T\u7ec6\u80de\u7684\u65b9\u5f0f\u4ea7\u751fIgM\u6297\u4f53\u6765\u62b5\u6297\u8840\u6db2\u4e2d\u7684\u75c5\u539f\u4f53\u3002<\/p>\n

\u7279\u522b\u4ee4\u4eba\u611f\u5174\u8da3\u7684\u662f\u5148\u5929\u6837b\u7ec6\u80de\u7684\u7ec4\u7ec7\u5b9a\u4f4d\uff0c\u5b83\u4e3b\u8981\u5728\u7c98\u819c\u8868\u9762\u548c\u80a0\u5185\u53d1\u6325\u4f5c\u7528\uff0c\u5728\u8fd9\u4e9b\u4f4d\u7f6eb1-\u6d46\u7ec6\u80de\u4ea7\u751f\u7684IgA\u53ef\u81ea\u53d1\u5b58\u5728\uff0c\u5e76\u4e0e\u80a0\u9053\u83cc\u7fa4\u53d1\u751f\u53cd\u5e94\u3002\u5728\u6210\u5e74\u5c0f\u9f20\u548c\u4eba\u4e2d\uff0c\u80a0\u7c98\u819c\u4e5f\u662f\u03b3\u03b4t\u6dcb\u5df4\u7ec6\u80de\u6700\u4e30\u5bcc\u7684\u90e8\u4f4d\uff0c\u5176\u6b21\u662f\u547c\u5438\u4e0a\u76ae(24)\u548c\u8868\u76ae\u3002\u7c98\u819c\u7ec4\u7ec7\u5728\u53ef\u80fd\u611f\u67d3\u7684\u8fc7\u7a0b\u4e2dmILL\u79cd\u7cfb\u7ec6\u80de\u53d7\u4f53\u53ef\u4ee5\u5feb\u901f\u53cd\u5e94\uff0c\u4ece\u800c\u63d0\u4f9b\u72ec\u7acb\u4e8e\u9002\u5e94\u6027\u53cd\u5e94\u4fdd\u62a4\uff0c\u5728\u6ca1\u6709\u6297\u539f\u66b4\u9732\u7684\u60c5\u51b5\u4e0b\uff0c\u4f8b\u5982\u5728\u65b0\u751f\u513f\u4e2d\u3002<\/p>\n

\u9c7c\u7c7b\u6dcb\u5df4\u7ec6\u80de<\/strong><\/p>\n

\u524d\u9762\u5bf9mILL\u505a\u4e86\u7b80\u77ed\u7684\u6982\u62ec\uff0c\u5728\u786c\u9aa8\u9c7c\u4e2d\u4f3c\u4e4e\u4e0e\u6211\u4eec\u6240\u77e5\u7684\u4f20\u7edf\u6dcb\u5df4\u7ec6\u80de\u7684\u7279\u5f81\u975e\u5e38\u76f8\u4f3c\uff0c\u5728\u6570\u5341\u5e74\u7684\u7814\u7a76\u4e2d\u79ef\u7d2f\u7684\u5b9e\u9a8c\u6570\u636e\u663e\u793a\uff0c\u6709\u8868\u9762\u03b1\u03b2-\u548c\u03b3\u03b4-tcr\u7684t\u7ec6\u80de\u3001\u8868\u8fbe\u4e09\u79cd\u514d\u75ab\u7403\u86cb\u767d\u7c7b\u578b(igm\u3001igt\u548cigd)\u7684b\u7ec6\u80de\u3001\u6dcb\u5df4\u7ec6\u80de\u4e9a\u7fa4\u4ee5\u53ca\u4e00\u6574\u5957\u7f16\u7801\u6dcb\u5df4\u7ec6\u80de\u76f8\u5173\u5206\u5b50\u7684\u4e3b\u57fa\u56e0\u3002\u5728\u4f53\u5916\u548c\u4f53\u5185\uff0c\u9c7c\u7c7b\u6dcb\u5df4\u7ec6\u80de\u88ab\u8bc1\u660e\u5177\u6709\u529f\u80fd\u6d3b\u6027\uff0c\u5e76\u4ea7\u751f\u548c\/\u6216\u53d7\u6dcb\u5df4\u7ec6\u80de\u76f8\u5173\u7ec6\u80de\u56e0\u5b50\u5bb6\u65cf\u7684\u5f71\u54cd\u3002<\/p>\n

\u9c7c\u7c7b<\/strong>T<\/strong>\u7ec6\u80de\u7684\u7279\u5f81<\/strong><\/p>\n

\u786c\u9aa8\u9c7c\u4e2d\u5b58\u5728\u4e24\u7c7bt\u7ec6\u80de\uff0c\u5728\u7ec6\u80de\u8868\u9762\u663e\u793a\u03b1\u03b2-\u548c\u03b3\u03b4-TcR\uff0c\u4e0eTCR\u5171\u53d7\u4f53\uff0c\u57fa\u56e0\u7684\u8868\u8fbe\u6a21\u5f0f\u660e\u786e\u5730\u8868\u660eT\u7ec6\u80de\u4e9a\u7fa4\u7684\u5b58\u5728\u5c31\u50cf\u5728\u54fa\u4e73\u52a8\u7269\u4e2d\u5df2\u77e5\u7684\u90a3\u6837\u3002\u5373cytotoxic (CD8), helper (CD4), and regulatory (Treg, Th17)\u3002\u8fd1\u5e74\u6765\uff0c\u9c7c\u7c7bt\u7ec6\u80de\u7684\u514d\u75ab\u751f\u7269\u5b66\u5df2\u6210\u4e3a\u7814\u7a76\u8c03\u63a7\u673a\u5236\u3001\u8868\u9762\u6807\u8bb0\u7269\u7684\u8868\u8fbe\u548c\u4f53\u5916\/\u4f53\u5185\u7814\u7a76\u7684\u91cd\u8981\u8bfe\u9898\u3002\u5c31\u76ee\u524d\u7684\u5de5\u4f5c\u800c\u8a00\uff0c\u73b0\u6709\u6570\u636e\u8868\u660e\uff0ct\u7ec6\u80de\u5728\u9c7c\u7c7b\u4e2d\u7684\u5206\u5e03\u4e3b\u8981\u5206\u5e03\u5728\u80a0\u548c\u9cc3\u7c98\u819c\u7ec4\u7ec7\u4e2d\uff0c\u800ct\u7ec6\u80de\u7684\u6d3b\u52a8\u5728\u8fd9\u4e9b\u7ec4\u7ec7\u4e2d\u662f\u591a\u79cd\u591a\u6837\u7684\u3002\u5728\u80a0\u9053\u5185\uff0cIEL\u8868\u73b0\u51fa\u4f53\u5916\u81ea\u53d1\u7684\u7ec6\u80de\u6bd2\u6d3b\u6027\uff0c\u589e\u503c\u80fd\u529b\u5dee\uff08\u672a\u516c\u5f00\u51fa\u7248\u53d1\u884c\u7684; \u672a\u53d1\u8868\u8fc7\u7684\uff09\uff0c\u5e76\u5728\u6ca1\u6709\u6297\u539f\u523a\u6fc0\u7684\u60c5\u51b5\u4e0b\u5e76\u5728\u4f53\u5185\u8fdb\u884cRAG-\u9a71\u52a8\u7684\u5728TcR\u03b2-chain\/TcR\u03b3-chain\u8fde\u63a5\u957f\u5ea6\u4e2d\u7ed9\u5b9a\u7684v\/c\u7ec4\u5408\u81ea\u53d1\u4f53\u7ec6\u80de\u91cd\u6392\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u6765\u81ea\u9cc3\u7684t\u7ec6\u80de\u53ef\u4ee5\u5728\u4f53\u5916\u589e\u6b96\u5bf9\u51dd\u96c6\u7d20\u4ea7\u751f\u53cd\u5e94\uff0c\u4f46rag\u7684\u8868\u8fbe\u662f\u53ef\u4ee5\u5ffd\u7565\u4e0d\u8ba1\u7684\u3002\u8fd9\u4e9b\u89c2\u5bdf\u8868\u660e\uff0c\u786c\u9aa8\u9c7c\u7684\u80a0\u9053\u53ef\u80fd\u662ft\u7ec6\u80de\u4ea7\u751f\u7684\u573a\u6240\uff0c\u800c\u9cc3\u5219\u53ef\u80fd\u662ft\u7ec6\u80de\u66f4\u591a\u53d1\u6325\u6548\u5e94\/\u8f85\u52a9\u4f5c\u7528\u7684\u573a\u6240\u3002\u9c7c\u7c7b\u80a0\u9053\u53ef\u4ee5\u6210\u4e3at\u7ec6\u80de\u7684\u4e3b\u8981\u4ea7\u751f\u8005\uff0c\u8fd9\u4e00\u5047\u8bf4\u7684\u652f\u6301\u6765\u81ea\u4e8e\u5173\u4e8e\u9c88\u9c7c\u514d\u75ab\u7cfb\u7edf\u53d1\u80b2\u7684\u6570\u636e\uff0c\u5373\u5728\u53d1\u80b2\u4e2d\u7684\u80a0\u9053\u4e4b\u524d\u6216\u540c\u65f6\u53d1\u73b0\u7b2c\u4e00\u6297\u4f53\u9633\u6027\u7684t\u7ec6\u80de\uff0c\u800c\u4e0d\u662f\u5728\u80f8\u817a\u4e2d\u68c0\u6d4b\u5230\u3002\u7136\u800c\uff0c\u786e\u5b9a\u9c7c\u7c7bt\u7ec6\u80de\u4e9a\u7fa4\u51fa\u73b0\u7684\u7cbe\u786e\u65f6\u95f4\u548c\u7ec4\u7ec7\u7684\u786e\u5207\u77e5\u8bc6\u4ecd\u7136\u7f3a\u4e4f\u3002\u6700\u540e\uff0c\u9c7c\u7c7b\u786e\u5b9e\u6709\u8bb0\u5fc6t\u7ec6\u80de\uff0c\u8fd9\u662f\u901a\u8fc7\u514d\u75ab\u9ca4\u9c7c\u7531il-10\u8c03\u5236CD8\u548cCD4\u7fa4\u4f53\u7684\u53cd\u5e94\u548c\u589e\u6b96\u6765\u8bc6\u522b\u7684\u3002\u6709\u8da3\u7684\u662f\uff0c\u9700\u8981\u6ce8\u610f\u7684\u662f\uff0c\u7531\u4e8e\u7f3a\u4e4f\u4f53\u7ec6\u80de\u91cd\u7ec4\u800c\u8bbe\u8ba1\u7684\u53d8\u5f02\u6591\u9a6c\u9c7c(rag-1\u2212\/\u2212)\u5728\u7ec6\u83cc\u518d\u6b21\u66b4\u9732\u540e\u4ecd\u7136\u80fd\u591f\u63d0\u4f9b\u7279\u5b9a\u7684\u4fdd\u62a4\u3002\u5927\u897f\u6d0b\u9cd5\u9c7c\u57fa\u56e0\u7ec4\u4e2d\u7f3a\u4e4fCD4\u548cmhc\u2161\uff0c\u4f46\u5728\u5bf9\u75c5\u539f\u4f53\u7684\u514d\u75ab\u6311\u6218\u4e2d\u53d7\u5230\u4fdd\u62a4\u3002\u8fd9\u4e9b\u89c2\u5bdf\u8868\u660e\uff0c\u9700\u8981\u5bf9\u9c7c\u7c7b\u8fdb\u884c\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\uff0c\u4ee5\u66f4\u597d\u5730\u9610\u660et\u7ec6\u80de\u7684\u529f\u80fd\u7279\u5f81\uff0c\u5982\u03b3\u03b4T\u7ec6\u80de\u7684\u541e\u566c\u80fd\u529b\u3002<\/p>\n

\u9c7c\u7c7bB\u7ec6\u80de\u7684\u7279\u5f81<\/strong><\/p>\n

\u53d1\u73b0\u9c7c\u7c7b\u4f53\u5185\u4ea7\u751f\u6297\u539f\u7279\u5f02\u6027\u6297\u4f53\u5df2\u7ecf\u6709\u8fd170\u5e74\u7684\u5386\u53f2\u4e86\uff0c\u7814\u7a76\u8868\u660e\uff0c\u9c7c\u7c7b\u7684b\u7ec6\u80de\u8868\u8fbe\u4e09\u79cd\u91cd\u7684Ig\u94fe\uff0c\u5373IgM, IgT\/Z\u548cIgD, \u5206\u522b\u901a\u8fc7\u8868\u8fbe\u03bc, \u03c4, and \u03b4\u6765\u5b9a\u4e49\u7684\u3002\u4ee5\u53ca\u4e00\u4e9bIg\u8f7b\u94fe(e.g., two in catfish, three in zebrafish, MW 25\u201328 kDa)\u3002IGM\u5728\u9c7c\u7c7b\u4e2d\u662f\u56db\u805a\u4f53(Mw 450 Kda)\uff0c\u7cfb\u7edf\u5730\u5b58\u5728\u4e8e\u4f53\u6db2\u4e2d\uff0c\u5b83\u4eec\u53ef\u80fd\u5728\u9ad8\u6d53\u5ea6\u65f6\u51fa\u73b0\u5728\u8840\u6e05\u4e2d\u3002IgT\/IgZ\u662f\u4ee5\u5355\u805a\u5f62\u5f0f(Mw 170 Kda)\u4ea7\u751f\u7684\u7c98\u819c\u514d\u75ab\u7403\u86cb\u767d\uff0c\u7136\u800c\u5728\u9cdf\u9c7c\u7c98\u6db2\u4e2d\u89c2\u5bdf\u5230\u4e00\u79cd\u975e\u5171\u4ef7\u7684\u805a\u5408IgT\u7ed3\u5408\u3002IgD\u5df2\u7ecf\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u5b83\u662f\u4ee5\u4e00\u79cd\u5355\u4f53\u7684\u5f62\u5f0f\u8868\u8fbe\u7684\uff0c\u5176\u5206\u5b50\u91cf\u4e3a150 kda\uff0c\u4f46\u5bf9\u5176\u5728\u9c7c\u7c7b\u4e2d\u7684\u751f\u7406\u4f5c\u7528\u77e5\u4e4b\u751a\u5c11\u3002\u540c\u6837\u5730\uff0c\u9c7c\u7684b\u7ec6\u80de\u4e5f\u662f\u8bb8\u591a\u7814\u7a76\u7684\u5bf9\u8c61\uff0c\u5176\u7ed3\u679c\u4e5f\u88ab\u7efc\u5408\u8bc4\u8bba\u3002\u5173\u4e8e\u76ee\u524d\u7684\u5de5\u4f5c\uff0c\u9c7c\u7c7bb\u7ec6\u80de\u7684\u4e3b\u8981\u6d3b\u52a8\u53ef\u6982\u62ec\u5982\u4e0b\uff1a\uff08i\uff09\u5728\u672a\u514d\u75ab\u7684\u9c7c\u7684\u5929\u7136\u8840\u6e05\u4e2dIgM\u7684\u542b\u91cf\u9ad8\uff1b\uff08ii\uff09\u4e8c\u6b21\u514d\u75ab\u540eIgM\u4eb2\u548c\u529b\u4e0b\u964d\uff1b\uff08iii\uff09\u5b58\u5728\u8bb0\u5fc6B\u7ec6\u80de\uff1b\uff08iv\uff09\u81ea\u53d1\u541e\u566c\u4f5c\u7528\uff1b\uff08v\uff09\u75c5\u539f\u4f53\u8bf1\u5bfc\u7c98\u819c\u5206\u6cccIgT\uff08IgA\u7684\u8fdb\u5316\u540c\u6e90\u7269\uff09\uff1b\uff08vi\uff09\u5b58\u5728\u7c7b\u4f3c\u5c0f\u9f20\u813eb1-b\u7ec6\u80de\u7684\u80be\u6dcb\u5df4\u7ec6\u80de\u524d\u4f53\uff1b\uff08vii\uff09\u8179\u819c\u8154\u4e2d\u5b58\u5728\u589e\u6b96\u6027b\u7ec6\u80de\uff1b\u53ef\u80fd\u8868\u8fbeTLRs\u3002\u6709\u8da3\u7684\u662f\uff0c\u5728\u4e00\u4e9b\u9c7c\u7c7b\u7269\u79cd\u4e2d\u89c2\u5bdf\u5230\u4e86\u6709\u5173b\u7ec6\u80de\u7684\u8010\u4eba\u5bfb\u5473\u7684\u7279\u5f81\uff0c\u4f8b\u5982\uff0c\u5728\u6210\u529f\u5730\u5bf9\u75c5\u539f\u4f53\u8fdb\u884c\u514d\u75ab\u540e\uff0c\u5c0f\u4f53\u7f3a\u4e4f\u75c5\u539f\u4f53\u7279\u5f02\u6027\u7684IgM\uff0c\u4ee5\u53ca\u5728\u4e00\u4e2a\u8154\u68d8\u9c7c\u4e2d\u7f3a\u4e4f\u5b8c\u6574\u7684IgM\u57fa\u56e0\u3002<\/p>\n

\u54fa\u4e73\u52a8\u7269\u5148\u5929\u6dcb\u5df4\u7ec6\u80de\u548c\u9c7c\u7c7b\u6dcb\u5df4\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4f3c\u6027<\/strong><\/p>\n

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\"\"<\/p>\n

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\u539f\u6587\uff1ahttps:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2018.00971\/full<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Abstract\uff1a\u6dcb\u5df4\u7ec6\u80de\u662f\u9002\u5e94\u6027\u53cd\u5e94\u7684\u8d23\u4efb\u8005\uff0c\u5c31\u50cf\u7ecf\u5178\u63cf\u8ff0\u7684\u90a3\u6837\uff0c\u4f46\u6709\u8bc1\u636e\u8868\u660e\uff0c\u54fa\u4e73\u52a8\u7269\u6dcb\u5df4\u7ec6\u80de\u7684\u4e9a\u7fa4\u53ef\u80fd\u8868\u73b0\u4e3a\u5148\u5929\u6837\u7ec6\u80de\uff0c\u5feb\u901f\u5730\u53c2\u4e0e\u975e\u81ea\u6211\u6d3b\u52a8\uff0c\u6ca1\u6709\u6297\u539f\u5448\u9012\u3002\u54fa\u4e73\u52a8\u7269\u4f53\u5185\u7684\u7c7b\u6dcb\u5df4\u7ec6\u80de\u4e3b\u8981\u662f\u03b3\u03b4t\u7ec6\u80de\u548cb1-b\u7ec6\u80de\uff0c\u4e3b\u8981\u5728\u7c98\u819c\u7ec4\u7ec7\u4e2d\u53d1\u6325\u4f5c\u7528\u3002\u53ef\u80fd\u4e0e\u4eba\u7c7b\u7684\u75c5\u7406\u6709\u5173\uff0c\u5176\u529f\u80fd\u548c\u7ec4\u7ec7\u7684\u8d77\u6e90\u5c1a\u4e0d\u5b8c\u5168\u6e05\u695a\u3002\u7531\u4e8e\u9c7c\u7c7b\u548c\u54fa\u4e73\u52a8\u7269\u7684\u514d\u75ab\u7cfb\u7edf\u5728\u5f62\u6001\u548c\u514d\u75ab\u751f\u7269\u5b66\u4e0a\u7684\u76f8\u4f3c\u6027\uff0c\u4ee5\u53ca\u5177\u6709\u81ea\u7531\u751f\u6d3b\u7684\u5e7c\u866b\u9636\u6bb5\u7684\u72ec\u7279\u6027\uff0c\u53ef\u4ee5\u7cbe\u786e\u5730\u76d1\u6d4b\u548c\u6539\u9020\u5b83\u4eec\u7684\u53d1\u80b2\uff0c\u56e0\u6b64\u63d0\u51fa\u4e86\u4e00\u79cd\u7814\u7a76\u4eba\u7c7b\u514d\u75ab\u7684\u5b9e\u9a8c\u6a21\u578b-\u786c\u9aa8\u9c7c\u3002\u7136\u800c\uff0c\u9c7c\u7c7b\u6dcb\u5df4\u7ec6\u80de\u4e0e\u54fa\u4e73\u52a8\u7269\u5148\u5929\u6837\u6dcb\u5df4\u7ec6\u80de\u4e4b\u95f4\u7684\u540c\u6e90\u6027\u662f\u6bd4\u8f83\u514d\u75ab\u5b66\u4e2d\u8003\u8651\u8f83\u5c11\u7684\u4e00\u4e2a\u95ee\u9898\u3002\u8d8a\u6765\u8d8a\u591a\u7684\u5b9e\u9a8c\u8bc1\u636e\u8868\u660e\uff0c\u9c7c\u7c7b\u6dcb\u5df4\u7ec6\u80de\u5728\u53d1\u80b2\u3001\u5f62\u6001\u548c\u529f\u80fd\u7279\u5f81\u4e0a\u53ef\u80fd\u4e0e\u54fa\u4e73\u52a8\u7269\u7684\u5148\u5929\u6837\u6dcb\u5df4\u7ec6\u80de\u6709\u5171\u540c\u4e4b\u5904\u3002\u5c3d\u7ba1\u6709\u8fd9\u4e9b\u76f8\u4f3c\u4e4b\u5904\uff0c\u4f46\u5173\u4e8e\u4f20\u7edf\u9c7c\u7c7b\u6dcb\u5df4\u7ec6\u80de\u548c\u54fa\u4e73\u52a8\u7269\u5148\u5929\u6837\u6dcb\u5df4\u7ec6\u80de\u4e4b\u95f4\u53ef\u80fd\u5b58\u5728\u8054\u7cfb\u7684\u4fe1\u606f\u4ecd\u7136\u7f3a\u4e4f\u3002\u672c\u6587\u65e8\u5728\u603b\u7ed3\u548c\u63cf\u8ff0\u9c7c\u7c7b\u6dcb\u5df4\u7ec6\u80de\u4e0e\u54fa\u4e73\u52a8\u7269\u5148\u5929\u6837\u6dcb\u5df4\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4f3c\u6027\uff0c\u652f\u6301\u54fa\u4e73\u52a8\u7269\u03b3\u03b4t\u7ec6\u80de\u548cb1-b\u7ec6\u80de\u53ef\u80fd\u4e0e\u9c7c\u7c7b\u6dcb\u5df4\u7ec6\u80de\u8fdb\u5316\u76f8\u5173\u7684\u5047\u8bf4\u3002 Introduction\uff1a\u53ea\u67092%\u7684\u540e\u751f\u52a8\u7269\u5b58\u5728\u5177\u6709mhc\u3001rag\u3001 memory 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NKT\u662f\u03b1\u03b2-\u548c\u03b3\u03b4-t\u7ec6\u80de\u7684\u4e00\u4e2a\u4e9a\u7fa4\u4f53\uff0c\u4e0eNK\u7ec6\u80de\u4e0d\u540c\uff0c\u5176\u7279\u5f81\u662fCD1d\u9650\u5236\u548c\u6709\u9650\u7684tcr\u591a\u6837\u6027\u3002\u5b83\u4eec\u4e3b\u8981\u5b58\u5728\u4e8e\u975e\u7c98\u819c\u7ec4\u7ec7\u4e2d\uff0c\u53c2\u4e0e\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u6709\u52a9\u4e8eb\u7ec6\u80de\u7684\u589e\u6b96\u548c\u6297\u4f53\u7684\u4ea7\u751f\u3002NKT\u53ef\u8fdb\u4e00\u6b65\u5206\u4e3a\u4e24\u4e2a\u4e0d\u540c\u7684\u4e9a\u7fa4\uff0c\u5373\u2160\u578b\u548c\u2161\u578bNKT\u7ec6\u80de\uff0c\u5b83\u4eec\u4f18\u5148\u4f4d\u4e8e\u809d\u810f\u5185\u3002\u2160\u578b\u5728\u5c0f\u9f20\u4e0a\u663e\u793a\u534a\u4e0d\u53d8TcR (V\u03b114J\u03b118\/V\u03b22, 7, 8)\uff0c\u5728\u4eba\u8eab\u4e0a\u663e\u793a(V\u03b124J\u03b118\/V\u03b211)\uff0c\u800c\u2161\u578bNKT\u7ec6\u80de\u8868\u73b0\u51fa\u66f4\u591a\u6837\u5316\u7684TCR\u5e8f\u5217\u3002 \u5148\u5929\u6837B\u6dcb\u5df4\u7ec6\u80de \u54fa\u4e73\u52a8\u7269\u7684b\u6dcb\u5df4\u7ec6\u80de\u73b0\u5728\u88ab\u5206\u7c7b\u4e3ab2\uff0c\u6216\u7ecf\u5178\u7684\uff0cb1\uff0c\u6216\u5148\u5929\u7684\u3002\u901a\u8fc7 Cd5\u5728\u5176\u8868\u9762\u7684\u5dee\u5f02\u5b9a\u4e49\u8fd9\u4e24\u7ec4\u4e3b\u8981\u7684b\u6dcb\u5df4\u7ec6\u80de\u3002B1a (B1)\u7ec6\u80de\u8fdb\u4e00\u6b65\u7ec6\u5206\u4e3aB1-B\uff0c\u8868\u578bCD5+\/IgMhigh\/IgDlow\uff0c\u548cCD5\u9634\u6027\u7684B-1b\u3002b1-b\u7ec6\u80de\u4ee5\u4e0d\u4f9d\u8d56T\u7ec6\u80de\u7684\u65b9\u5f0f\u4ea7\u751f\u5927\u91cf\u5929\u7136\u591a\u53cd\u5e94\u6297\u4f53\uff0c\u662f\u79ef\u6781\u541e\u566c\u548c\u6740\u5fae\u751f\u7269\uff0c\u53ef\u80fd\u53c2\u4e0e\u81ea\u8eab\u514d\u75ab\uff0c\u5728\u611f\u67d3\u671f\u95f4\uff0c\u5b83\u4eec\u5728\u80a0\u7c98\u819c\u4e2d\u4ee5\u5206\u6ccciga\u7684\u6d46\u7ec6\u80de\u7684\u5f62\u5f0f\u5b58\u5728\u3002CD5+ 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