{"id":682,"date":"2021-03-09T21:15:12","date_gmt":"2021-03-09T13:15:12","guid":{"rendered":"http:\/\/www.wuchangsong.com\/?p=682"},"modified":"2021-04-13T17:48:11","modified_gmt":"2021-04-13T09:48:11","slug":"%e8%b7%a8%e7%89%a9%e7%a7%8d%e6%af%94%e8%be%83%e8%bd%ac%e5%bd%95%e7%bb%84","status":"publish","type":"post","link":"http:\/\/www.wuchangsong.com\/?p=682","title":{"rendered":"\u8de8\u7269\u79cd\u6bd4\u8f83\u8f6c\u5f55\u7ec4"},"content":{"rendered":"<p>\u8fd1\u51e0\u5e74\u51e0\u7bc7\u9ad8\u5206\u6587\u732e\u5bf9\u8de8\u7269\u79cd\u6bd4\u8f83\u8f6c\u5f55\u7ec4\u65b9\u6cd5\u7684\u5e94\u7528\u53ca\u7814\u7a76\u9886\u57df\uff0c\u611f\u5174\u8da3\u7684\u53ef\u81ea\u884c\u67e5\u770b\u539f\u6587\u732e\uff1a<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.cell.2019.11.010\">Cell_2019_\u8de8\u7269\u79cd\u5355\u7ec6\u80de\u6d4b\u5e8f\u63ed\u793a\u5c0f\u80f6\u8d28\u7ec6\u80de\u57fa\u56e0\u8868\u8fbe\u8c31\u8fdb\u5316\u7279\u5f81<\/a><\/p>\n<p><a href=\"http:\/\/dx.doi. org\/10.1126\/ science.aay5947\">Science_2020_\u4eba\u7c7b\u732a\u5c0f\u9f20\u5927\u8111\u4e2d\u7684\u86cb\u767d\u7f16\u7801\u57fa\u56e0\u56fe\u8c31<\/a><\/p>\n<p><a href=\"http:\/\/dx.doi. org\/10.1126\/ science.aat8077\">Science_2018_\u8de8\u4eba\u7c7b\u548c\u7315\u7334\u5927\u8111\u53d1\u80b2\u7684\u65f6\u7a7a\u8f6c\u5f55\u7ec4\u5dee\u5f02<\/a><\/p>\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.cell.2021.01.047\">Cell_2021_African lungfish genome sheds lighton the vertebrate water-to-landtransition<\/a><\/p>\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.cell.2021.01.001\">Cell_2021_\u4eba\u7c7b\u5927\u8111\u8fdb\u5316\u7684\u53d1\u80b2\u8c03\u63a7\u673a\u5236<\/a><\/p>\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.cell.2021.01.046\">Cell_2021_\u539f\u59cb\u8f90\u9ccd\u9c7c\u7c7b\u57fa\u56e0\u7ec4\u7684\u89e3\u6790\u53d1\u73b0\u767b\u9646\u7684\u9057\u4f20\u57fa\u7840\u5df2\u7ecf\u5728\u786c\u9aa8\u9c7c\u7c7b\u7956\u5148\u51fa\u73b0<\/a><\/p>\n<p>\u770b\u5b8c\u4e0a\u8ff0\u6587\u732e\u53ef\u77e5\u548c\u79cd\u5185\u6bd4\u8f83\u8f6c\u5f55\u7ec4\u76f8\u6bd4\uff0c\u8de8\u7269\u79cd\uff08\u79cd\u95f4\uff09\u6bd4\u8f83\u8f6c\u5f55\u7ec4\u8981\u590d\u6742\u7684\u591a\uff0c\u4e3b\u8981\u4f53\u73b0\u5728\u80cc\u666f\u57fa\u56e0\u603b\u6570\u3001\u6d4b\u5e8f\u6df1\u5ea6\u3001\u7ba1\u5bb6\u57fa\u56e0\u8868\u8fbe\u8c31\u548c\u53ef\u80fd\u7684\u5176\u4ed6\u56e0\u7d20\u5dee\u5f02\u7b49\uff1b\u5206\u6790\u6d41\u7a0b\u4e3b\u8981\u5206\u4e3a\u4e24\u6b65\uff1a1\u3001\u76f4\u7cfb\u540c\u6e90\u57fa\u56e0\u7684\u67e5\u627e\u3002\u6b64\u5904\u5927\u90e8\u5206\u6587\u732e\u4f7f\u7528 <span class=\"fontstyle0\">one-to-one orthologs<\/span>\u00a0\uff08\u53ca\u53cc\u5411\u6700\u4f18\u6bd4\u5bf9\uff09\uff0c\u5982\u679c\u7269\u79cd\u8de8\u5ea6\u8f83\u5927\u53ef\u9009\u8f83\u4e3a\u5bbd\u677e\u7684\u9608\u503c\uff0c\u671f\u671b\u503c1e-10\uff0c\u8986\u76d6\u5ea650%\uff1b\u5982\u679c\u7269\u79cd\u4eb2\u7f18\u5173\u7cfb\u8f83\u4e3a\u63a5\u8fd1\u5c31\u9009\u8f83\u4e25\u7684\u9608\u503c\u3002\u4e5f\u6709\u6587\u732e\u5148\u83b7\u5f97\u76f4\u7cfb\u540c\u6e90\u57fa\u56e0\u5217\u8868\uff0c\u4e00\u4e2agene list\u53ca\u4e3a\u4e00\u4e2a\u57fa\u56e0\uff08matagene\uff09\uff0c\u8be5\u57fa\u56e0\u7684\u8868\u8fbe\u91cf\u4e3agene list\u6240\u6709\u57fa\u56e0\u8868\u8fbe\u91cf\u7684\u548c\uff08\u57fa\u56e0\u62f7\u8d1d\u6570\u5dee\u5f02\uff09\u30022\u3001\u5408\u5e76\u540e\u57fa\u56e0\u8868\u8fbe\u77e9\u9635\u7684\u6807\u51c6\u5316\u3002\u6807\u51c6\u5316\u65b9\u6cd5\u5404\u5f02\uff0c\u65b9\u6cd5\u4e4b\u4e00\uff1a\u9996\u5148\u5728\u79cd\u5185\u8ba1\u7b97\u51faFPKM\u3001RPKM\u3001TPM\u7b49\uff0c\u79cd\u5185TMM\u6807\u51c6\u5316\uff0c\u7136\u540e\u6839\u636e\u80cc\u666f\u57fa\u56e0\u96c6\u5408\u5e76\u6570\u636e\u5f97\u5230\u65b0\u7684\u8868\u8fbe\u77e9\u9635\u518d\u4f7f\u7528TMM\u6807\u51c6\u5316\u3002\u4e5f\u6709\u76f4\u63a5<span class=\"fontstyle0\">quantile normalization using the R package preprocessCore\uff08\u5177\u4f53R\u5b9e\u73b0\u53ef\u53c2\u8003\u4e0b\u7bc7\u6587\u7ae0\uff09\uff0c<\/span>\u6807\u51c6\u5316\u65b9\u6cd5\u7684\u9009\u62e9\u5bf9\u7ed3\u679c\u7684\u5f71\u54cd\u5f88\u5927\uff0c\u53ef\u81ea\u884c\u5c1d\u8bd5\u9002\u5408\u81ea\u5df1\u7684\u6807\u51c6\u5316\u65b9\u6cd5\u3002\u53e6\u5916\uff0c\u4e0d\u540c\u6570\u636e\u6765\u6e90\u9700\u8981\u53bb\u9664\u6279\u6b21\u6548\u5e94\uff0c\u4e0d\u7136\u8fdb\u884cPCA\u548c\u6837\u672c\u76f8\u5173\u6027\u5206\u6790\u65f6\u4f1a\u5c06\u4e0d\u540c\u6570\u636e\u6765\u6e90\u7684\u6837\u672c\u805a\u5230\u4e00\u5757\uff1b\u6570\u636e\u7684\u9002\u5f53\u7f29\u653e\u4e5f\u662f\u5fc5\u8981\u7684\uff0c\u4e00\u4e9b\u805a\u7c7b\u65b9\u6cd5\u4f1a\u5c06\u6781\u503c\u5e26\u6765\u7684\u5f71\u54cd\u653e\u5927\u5316\uff0c\u4f7f\u7ed3\u679c\u4e0d\u51c6\u786e\u3002\u4e0b\u56fe\u662f<a href=\"http:\/\/dx.doi. org\/10.1126\/ science.aay5947\">Science_2020_\u4eba\u7c7b\u732a\u5c0f\u9f20\u5927\u8111\u4e2d\u7684\u86cb\u767d\u7f16\u7801\u57fa\u56e0\u56fe\u8c31<\/a>\u5206\u6790\u6d41\u7a0b\u3002<\/p>\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" loading=\"lazy\" width=\"563\" height=\"447\" src=\"http:\/\/www.wuchangsong.com\/wp-content\/uploads\/2021\/04\/QQ\u56fe\u724720210413174621.png\" alt=\"\" class=\"wp-image-755\" srcset=\"http:\/\/www.wuchangsong.com\/wp-content\/uploads\/2021\/04\/QQ\u56fe\u724720210413174621.png 563w, http:\/\/www.wuchangsong.com\/wp-content\/uploads\/2021\/04\/QQ\u56fe\u724720210413174621-300x238.png 300w\" sizes=\"(max-width: 563px) 100vw, 563px\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>\u8fd1\u51e0\u5e74\u51e0\u7bc7\u9ad8\u5206\u6587\u732e\u5bf9\u8de8\u7269\u79cd\u6bd4\u8f83\u8f6c\u5f55\u7ec4\u65b9\u6cd5\u7684\u5e94\u7528\u53ca\u7814\u7a76\u9886\u57df\uff0c\u611f\u5174\u8da3\u7684\u53ef\u81ea\u884c\u67e5\u770b\u539f\u6587\u732e\uff1a Cell_2019_\u8de8\u7269\u79cd\u5355\u7ec6\u80de\u6d4b\u5e8f\u63ed\u793a\u5c0f\u80f6\u8d28\u7ec6\u80de\u57fa\u56e0\u8868\u8fbe\u8c31\u8fdb\u5316\u7279\u5f81 Science_2020_\u4eba\u7c7b\u732a\u5c0f\u9f20\u5927\u8111\u4e2d\u7684\u86cb\u767d\u7f16\u7801\u57fa\u56e0\u56fe\u8c31 Science_2018_\u8de8\u4eba\u7c7b\u548c\u7315\u7334\u5927\u8111\u53d1\u80b2\u7684\u65f6\u7a7a\u8f6c\u5f55\u7ec4\u5dee\u5f02 Cell_2021_African lungfish genome sheds lighton the vertebrate water-to-landtransition Cell_2021_\u4eba\u7c7b\u5927\u8111\u8fdb\u5316\u7684\u53d1\u80b2\u8c03\u63a7\u673a\u5236 Cell_2021_\u539f\u59cb\u8f90\u9ccd\u9c7c\u7c7b\u57fa\u56e0\u7ec4\u7684\u89e3\u6790\u53d1\u73b0\u767b\u9646\u7684\u9057\u4f20\u57fa\u7840\u5df2\u7ecf\u5728\u786c\u9aa8\u9c7c\u7c7b\u7956\u5148\u51fa\u73b0 \u770b\u5b8c\u4e0a\u8ff0\u6587\u732e\u53ef\u77e5\u548c\u79cd\u5185\u6bd4\u8f83\u8f6c\u5f55\u7ec4\u76f8\u6bd4\uff0c\u8de8\u7269\u79cd\uff08\u79cd\u95f4\uff09\u6bd4\u8f83\u8f6c\u5f55\u7ec4\u8981\u590d\u6742\u7684\u591a\uff0c\u4e3b\u8981\u4f53\u73b0\u5728\u80cc\u666f\u57fa\u56e0\u603b\u6570\u3001\u6d4b\u5e8f\u6df1\u5ea6\u3001\u7ba1\u5bb6\u57fa\u56e0\u8868\u8fbe\u8c31\u548c\u53ef\u80fd\u7684\u5176\u4ed6\u56e0\u7d20\u5dee\u5f02\u7b49\uff1b\u5206\u6790\u6d41\u7a0b\u4e3b\u8981\u5206\u4e3a\u4e24\u6b65\uff1a1\u3001\u76f4\u7cfb\u540c\u6e90\u57fa\u56e0\u7684\u67e5\u627e\u3002\u6b64\u5904\u5927\u90e8\u5206\u6587\u732e\u4f7f\u7528 one-to-one orthologs\u00a0\uff08\u53ca\u53cc\u5411\u6700\u4f18\u6bd4\u5bf9\uff09\uff0c\u5982\u679c\u7269\u79cd\u8de8\u5ea6\u8f83\u5927\u53ef\u9009\u8f83\u4e3a\u5bbd\u677e\u7684\u9608\u503c\uff0c\u671f\u671b\u503c1e-10\uff0c\u8986\u76d6\u5ea650%\uff1b\u5982\u679c\u7269\u79cd\u4eb2\u7f18\u5173\u7cfb\u8f83\u4e3a\u63a5\u8fd1\u5c31\u9009\u8f83\u4e25\u7684\u9608\u503c\u3002\u4e5f\u6709\u6587\u732e\u5148\u83b7\u5f97\u76f4\u7cfb\u540c\u6e90\u57fa\u56e0\u5217\u8868\uff0c\u4e00\u4e2agene list\u53ca\u4e3a\u4e00\u4e2a\u57fa\u56e0\uff08matagene\uff09\uff0c\u8be5\u57fa\u56e0\u7684\u8868\u8fbe\u91cf\u4e3agene list\u6240\u6709\u57fa\u56e0\u8868\u8fbe\u91cf\u7684\u548c\uff08\u57fa\u56e0\u62f7\u8d1d\u6570\u5dee\u5f02\uff09\u30022\u3001\u5408\u5e76\u540e\u57fa\u56e0\u8868\u8fbe\u77e9\u9635\u7684\u6807\u51c6\u5316\u3002\u6807\u51c6\u5316\u65b9\u6cd5\u5404\u5f02\uff0c\u65b9\u6cd5\u4e4b\u4e00\uff1a\u9996\u5148\u5728\u79cd\u5185\u8ba1\u7b97\u51faFPKM\u3001RPKM\u3001TPM\u7b49\uff0c\u79cd\u5185TMM\u6807\u51c6\u5316\uff0c\u7136\u540e\u6839\u636e\u80cc\u666f\u57fa\u56e0\u96c6\u5408\u5e76\u6570\u636e\u5f97\u5230\u65b0\u7684\u8868\u8fbe\u77e9\u9635\u518d\u4f7f\u7528TMM\u6807\u51c6\u5316\u3002\u4e5f\u6709\u76f4\u63a5quantile normalization using the R package preprocessCore\uff08\u5177\u4f53R\u5b9e\u73b0\u53ef\u53c2\u8003\u4e0b\u7bc7\u6587\u7ae0\uff09\uff0c\u6807\u51c6\u5316\u65b9\u6cd5\u7684\u9009\u62e9\u5bf9\u7ed3\u679c\u7684\u5f71\u54cd\u5f88\u5927\uff0c\u53ef\u81ea\u884c\u5c1d\u8bd5\u9002\u5408\u81ea\u5df1\u7684\u6807\u51c6\u5316\u65b9\u6cd5\u3002\u53e6\u5916\uff0c\u4e0d\u540c\u6570\u636e\u6765\u6e90\u9700\u8981\u53bb\u9664\u6279\u6b21\u6548\u5e94\uff0c\u4e0d\u7136\u8fdb\u884cPCA\u548c\u6837\u672c\u76f8\u5173\u6027\u5206\u6790\u65f6\u4f1a\u5c06\u4e0d\u540c\u6570\u636e\u6765\u6e90\u7684\u6837\u672c\u805a\u5230\u4e00\u5757\uff1b\u6570\u636e\u7684\u9002\u5f53\u7f29\u653e\u4e5f\u662f\u5fc5\u8981\u7684\uff0c\u4e00\u4e9b\u805a\u7c7b\u65b9\u6cd5\u4f1a\u5c06\u6781\u503c\u5e26\u6765\u7684\u5f71\u54cd\u653e\u5927\u5316\uff0c\u4f7f\u7ed3\u679c\u4e0d\u51c6\u786e\u3002\u4e0b\u56fe\u662fScience_2020_\u4eba\u7c7b\u732a\u5c0f\u9f20\u5927\u8111\u4e2d\u7684\u86cb\u767d\u7f16\u7801\u57fa\u56e0\u56fe\u8c31\u5206\u6790\u6d41\u7a0b\u3002<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"_links":{"self":[{"href":"http:\/\/www.wuchangsong.com\/index.php?rest_route=\/wp\/v2\/posts\/682"}],"collection":[{"href":"http:\/\/www.wuchangsong.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.wuchangsong.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.wuchangsong.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.wuchangsong.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=682"}],"version-history":[{"count":6,"href":"http:\/\/www.wuchangsong.com\/index.php?rest_route=\/wp\/v2\/posts\/682\/revisions"}],"predecessor-version":[{"id":838,"href":"http:\/\/www.wuchangsong.com\/index.php?rest_route=\/wp\/v2\/posts\/682\/revisions\/838"}],"wp:attachment":[{"href":"http:\/\/www.wuchangsong.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=682"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.wuchangsong.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=682"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.wuchangsong.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=682"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}