{"id":803,"date":"2021-12-14T00:43:48","date_gmt":"2021-12-13T16:43:48","guid":{"rendered":"http:\/\/www.wuchangsong.com\/?p=803"},"modified":"2021-12-14T00:44:38","modified_gmt":"2021-12-13T16:44:38","slug":"%e6%9c%89%e9%99%90%e7%9a%84%e6%8a%97%e5%8e%9f%e8%8e%b7%e5%8f%96%e9%a9%b1%e5%8a%a8%e6%97%a9%e6%9c%9fb%e7%bb%86%e8%83%9e%e8%ae%b0%e5%bf%86%e7%9a%84%e4%ba%a7%e7%94%9f%ef%bc%8c%e5%90%8c%e6%97%b6%e6%8a%91","status":"publish","type":"post","link":"http:\/\/www.wuchangsong.com\/?p=803","title":{"rendered":"\u6709\u9650\u7684\u6297\u539f\u83b7\u53d6\u9a71\u52a8\u65e9\u671fB\u7ec6\u80de\u8bb0\u5fc6\u7684\u4ea7\u751f\uff0c\u540c\u65f6\u6291\u5236\u6d46\u6bcd\u7ec6\u80de\u53cd\u5e94"},"content":{"rendered":"

\u8be5\u6587\u4e3a2021-09-14\u53d1\u8868\u5728Immunity\uff08IF=31.7\uff09\u9898\u4e3a\u2018Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response\u2019\u7684\u5b66\u4e60\u7b14\u8bb0\u3002<\/p>\n

\u6458\u8981<\/strong>
\u00a0 \u00a0 \u65e9\u671f B \u7ec6\u80de\u6fc0\u6d3b\u671f\u95f4\u7684\u7ec6\u80de\u547d\u8fd0\u51b3\u5b9a\u4e86\u5bf9\u75c5\u539f\u4f53\u548c\u75ab\u82d7\u7684\u53cd\u5e94\u7ed3\u679c\u3002 \u6211\u4eec\u901a\u8fc7\u5355\u7ec6\u80de RNA \u6d4b\u5e8f\u68c0\u67e5\u4e86\u5c0f\u9f20\u5bf9 T \u4f9d\u8d56\u6027\u6297\u539f\u7684\u65e9\u671f B \u7ec6\u80de\u53cd\u5e94\u3002 \u514d\u75ab\u63a5\u79cd\u540e\u65e9\u671f\uff0c \u540c\u8d28\u7684\u6d3b\u5316\u524d\u4f53 (AP) \u7fa4\u4f1a\u4ea7\u751f\u77ed\u6682\u7684\u6d46\u6bcd\u7ec6\u80de (PB)\uff0c \u4e00\u5929\u540e\u51fa\u73b0\u751f\u53d1\u4e2d\u5fc3 B \u7ec6\u80de (GCBC)\u3002 \u5927\u591a\u6570 AP \u8fc5\u901f\u9000\u51fa\u7ec6\u80de\u5468\u671f\uff0c \u4ea7\u751f\u975e GC \u884d\u751f\u7684\u65e9\u671f\u8bb0\u5fc6 B \u7ec6\u80de (eMBC)\uff0c \u4fdd\u7559\u4e86\u7c7b\u4f3c AP \u7684\u8f6c\u5f55\u8c31\u3002 \u6297\u539f\u53ef\u7528\u6027\u7684\u5feb\u901f\u4e0b\u964d\u63a7\u5236\u4e86\u8fd9\u4e9b\u4e8b\u4ef6\uff1b \u63d0\u4f9b\u8fc7\uf97e\u6297\u539f\u4f1a\u963b\u6b62\u7ec6\u80de\u5468\u671f\u9000\u51fa\u5e76\u5f15\u53d1\u65b0\u4e00\u6ce2\u7684 PB\u3002 \u547d\u8fd0\u6620\u5c04\u63ed\u793a\u4e86 eMBC \u5bf9 MBC \u6c60\u7684\u7a81\u51fa\u8d21\u732e\u3002 \u5177\u6709 MBC \u8868\u578b\u7684\u9759\u606f\u7ec6\u80de\u4e3b\u5bfc\u4e86\u7075\u957f\u7c7b\u52a8\u7269\u5bf9\u514d\u75ab\u7684\u65e9\u671f\u53cd\u5e94\u3002 \u5f53\u6297\u539f\u53ef\u7528\u6027\u589e\u52a0\u8868\u660e\u672a\u80fd\u904f\u5236\u5a01\u80c1\u65f6\uff0cAPs\/eMBCs \u5e93\u53ef\u4ee5\u4f7f\u514d\u75ab\u53cd\u5e94\u5feb\u901f\u91cd\u65b0\u8c03\u6574\u3002<\/p>\n

\u80cc\u666f<\/strong><\/p>\n

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\u7ed3\u679c<\/strong>
1. scRNA-seq\u68c0\u6d4b\u4e86\u514d\u75ab\u524d3.5\u5929\u548c4\u5929\u6297\u539f\u7279\u5f02B\u7ec6\u80de\u7684\u4e09\u4e2a\u6548\u5e94\u8c31\u7cfb\u3002 \u57fa\u56e0\u8868\u8fbe\u7279\u5f81\u7684\u5206\u6790\u8868\u660e\uff0c \u6839\u636e PB \u7684\u8868\u8fbe\u5224\u65ad\uff0c \u6700\u5c0f\u7684\u7ec6\u80de\u7fa4\u5bf9\u5e94\u4e8e PBIrf4, prdm1 (BLIMP1) \u548c Xbp1\uff0c \u7f16\u7801 PB\u548c PC \u7684\u8c31\u7cfb\u5b9a\u4e49\u8f6c\u5f55\u56e0\u5b50\uff0c \u4ee5\u53ca B \u7ec6\u80de\u7a0b\u5e8f\u76f8\u5173\u57fa\u56e0\u7684\u4e0b\u8c03\u3002\u7b2c\u4e8c\u7ec6\u80de\u7fa4\u4f53\u5bf9\u5e94\u4e8eGCBCs\uff0c\u8fd9\u53ef\u4ee5\u901a\u8fc7\u5b83\u4eec\u5bf9bcl6\u4ee5\u53cagcsam\u548crgs13(\u7f16\u7801gcbcs\u9ad8\u8868\u8fbe\u7684\u4fe1\u53f7\u4f20\u611f\u5668)\u7684\u8868\u8fbe\u6765\u8bc1\u660e\u3002 \u6700\u5927\u7684\u7ec6\u80de\u7fa4\u8868\u8fbeCcr6\u3002pbs\u4ecegcbc\u548cccr6\u7ec6\u80de\u7fa4\u4e2d\u5b8c\u5168\u5206\u79bb\uff0c\u800cgcbcs\u4e0e\u5176\u4ed6\u7fa4\u4f53\u4e5f\u8868\u73b0\u51fa\u9ad8\u5ea6\u7684\u5206\u79bb\uff0c\u5728umap\u548c\u4e3b\u6210\u5206\u5206\u6790(pca)\u4e2d\u4e0eccr6\u7ec6\u80de\u5206\u79bb\u3002<\/span><\/p>\n

2. \u5927\u90e8\u5206\u6d3b\u5316\u7684 B \u7ec6\u80de\u5728\u53cd\u5e94\u7684\u6700\u521d\u51e0\u5929\u5f00\u59cb\u9000\u51fa\u7ec6\u80de\u5468\u671f\uff0c \u8fd9\u4e9b\u975e GC \u884d\u751f\u7684 eMBC \u53ef\u4ee5\u4e3a\u957f\u5bff\u547d\u7684 MBC \u6c60\u505a\u51fa\u5f88\u5927\u8d21\u732e\u3002<\/span><\/p>\n

3. \u5927\u591a\u6570\u975egc\u884d\u751f\u7684pbs\u662f\u5728\u514d\u75ab\u540e\u65e9\u671f\u7684\u72ed\u7a84\u65f6\u95f4\u7a97\u53e3\u5185\u4ea7\u751f\u7684\uff0c\u5e76\u4e14aps\u5bf9pb\u5ba4\u7684\u8d21\u732e\u662f\u6709\u9650\u7684\u3002<\/span><\/p>\n

4. \u867d\u7136gcbcs\u548cpbs\u7684\u8f6c\u5f55\u7ec4\u5728\u7b2c4\u5929\u4e0eap-embc\u7fa4\u4f53\u4e0d\u540c\uff0c\u4f46\u7b2c50\u5929MBCs\u4e0e\u7b2c2.5\u5929\u548c\u7b2c4\u5929ap-embc\u7fa4\u4f53\u4fdd\u6301\u8f83\u9ad8\u7684\u8f6c\u5f55\u76f8\u4f3c\u6027\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u5f97\u51fa\u7ed3\u8bba\uff0cembcs\u5728\u8f6c\u5f55\u4e0a\u4ecd\u7136\u4e0e\u8fd9\u4e09\u4e2a\u8c31\u7cfb\u7684\u5171\u540caps\u76f8\u4f3c\u3002<\/span><\/p>\n

5. \u6709\u9650\u7684\u6297\u539f\u53ef\u7528\u6027\u6709\u52a9\u4e8e\u65e9\u671f\u7ec6\u80de\u5468\u671f \uff0cAP \u7684\u9000\u51fa\u548c\u989d\u5916\u6297\u539f\u7684\u63d0\u4f9b\uf967\u4ec5\u201c\u62ef\u6551\u201d\u4e86\u8fd9\u79cd\u4ece\u53cd\u5e94\u4e2d\u7684\u9000\u51fa\uff0c\u800c\u4e14\u8fd8\u589e\u5f3a\u4e86\u5411 PB \u8c31\u7cfb\u7684\u5206\u5316\u3002<\/span><\/p>\n

6. \u8bb8\u591a\u6d3b\u5316 B \u7ec6\u80de\u7684\u65e9\u671f\u7ec6\u80de\u5468\u671f\u9000\u51fa\uff0c \u53ef\u80fd\u8868\u73b0\u51fa\u5b83\u4eec\u7684 eMBC \u5206\u5316\uff0c\u4e5f\u53d1\u751f\u5728\u5bf9\u514d\u75ab\u548c\u611f\u67d3\u7684\u591a\u514b\uf9dc\u53cd\u5e94\u4e2d\u3002 <\/span><\/p>\n

7. \u7075\u957f\u7c7b\u52a8\u7269\u4e2d\u5f88\u5927\u4e00\u90e8\u5206\u6d3b\u5316\u7684b\u7ec6\u80de\u5728\u6700\u521d\u7684\u6269\u5f20\u540e\u4e0d\u4e45\u5c31\u4f1a\u9000\u51fa\u53cd\u5e94\u3002\u4e0e\u5c0f\u9f20\u4e00\u6837\uff0c\u8fd9\u4e9b\u7ec6\u80de\u4e0a\u8c03\u8bb0\u5fc6\u7ec6\u80de\u6807\u8bb0\u7269\uff0c\u800c\u8fd9\u4e9b\u5177\u6709mbc\u8868\u578b\u7684\u9759\u6b62\u7ec6\u80de\u7684\u51fa\u73b0\u4e0egcs\u5916\u6709\u9650\u7684\u6297\u539f\u53ef\u7528\u6027\u76f8\u4e00\u81f4\u3002\u56e0\u6b64\uff0c\u5728\u556e\u9f7f\u7c7b\u52a8\u7269\u548c\u7075\u957f\u7c7b\u52a8\u7269\u4e2d\uff0c\u80da\u80ce\u5e72\u7ec6\u80de\u7684\u5206\u5316\u4f3c\u4e4e\u5728\u8fdb\u5316\u4e0a\u662f\u4fdd\u5b88\u7684\u3002<\/p>\n

\u8ba8\u8bba<\/strong><\/p>\n

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